Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: A prospective phase II study

Giovanna Mantini, Vincenzo Valentini, Bruno Meduri, Stefano Margaritora, Mario Balducci, Francesco Micciché, Luigia Nardone, Fiorenza De Rose, Alfredo Cesario, Anna Rita Larici, Fabio Maggi, Maria Lucia Calcagni, Pierluigi Granone

Research output: Contribution to journalArticle

Abstract

Purpose: Low-dose radiotherapy (LDR) (2 IV) and concurrent LDR (40 cGy bid on days 1 and 2) delivered to target pulmonary or metastatic disease. This cycle was repeated fourfold every 21 days. The accrual was determined by the single proportion powered analysis (α = 0.05, power = 0.8) with H0 ("bad" response probability, 9% according to literature) and H1 ("good" response probability, 35% ongoing study); 19 is the number required. Results: Nineteen patients with stage III and IV disease were enrolled. Only one patient experienced neutropenia grade 4. All patients are evaluable for clinical response of irradiated lesion: overall response rate was 42%. Conclusions: Low-dose radiotherapy combined with pemetrexed has a similar toxicity profile to chemotherapy alone. The response rate of this novel approach is encouraging, since it was higher than what was reported for pemetrexed alone (42% versus 9.1%). Additional scientific investigation of this new treatment paradigm is warranted.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalRadiotherapy and Oncology
Volume105
Issue number2
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Chemopotentiator
  • Low dose hyper-radiosensitivity
  • Lung cancer
  • Pemetrexed
  • Radio-chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

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    Mantini, G., Valentini, V., Meduri, B., Margaritora, S., Balducci, M., Micciché, F., Nardone, L., De Rose, F., Cesario, A., Larici, A. R., Maggi, F., Calcagni, M. L., & Granone, P. (2012). Low-dose radiotherapy as a chemo-potentiator of a chemotherapy regimen with pemetrexed for recurrent non-small-cell lung cancer: A prospective phase II study. Radiotherapy and Oncology, 105(2), 161-166. https://doi.org/10.1016/j.radonc.2012.09.006