Ridotte dosi infusione di remifentanyl per l'analgo-sedazione in neonati in ventilazione meccanica

Translated title of the contribution: Low dose remifentanyl infusion for analgesia and sedation in ventilated newborns

F. Stoppa, D. Perrotta, C. Tomasello, C. Cecchetti, M. Marano, E. Pasotti, M. A. Barbieri, G. Conti, N. Pirozzi

Research output: Contribution to journalArticle

Abstract

Aim. The aim of this study was to evaluate the analgesic effects of remifentanyl® on mechanically ventilated newborns. Methods. Eighteen newborns, mechanically ventilated, were submitted to continuous infusion of R. A pain scale was used to evaluate comfort during mechanical ventilation. Data were collected at T0, T1, Tn, T ext, T post-ext; statistical analysis was performed by Student's t test and Pearson coefficient. Results. Mean R infusion time was 66.94±22.24 h, with mean dose of R 0.146±0.038 γ/kg/min. Mean time to reach comfort was 20±13.11 h with a mean infusion of R equal to 0.173±0.146 γ/kg/min; R was 0.18±0.039 γ/kg/min on pressure controlled ventilation and R was 0.09± 0.045 γ/kg/min on assisted ventilation. Statistically significant was considered the decrease in HR as well as the increase of SpO2 at T0 vs 30 min after infusion. Conclusion. No adverse effects were observed during and after infusion.

Original languageItalian
Pages (from-to)753-761
Number of pages9
JournalMinerva Anestesiologica
Volume70
Issue number11
Publication statusPublished - Nov 2004

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Analgesia
Ventilation
Newborn Infant
Artificial Respiration
Analgesics
Students
Pressure
Pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Ridotte dosi infusione di remifentanyl per l'analgo-sedazione in neonati in ventilazione meccanica. / Stoppa, F.; Perrotta, D.; Tomasello, C.; Cecchetti, C.; Marano, M.; Pasotti, E.; Barbieri, M. A.; Conti, G.; Pirozzi, N.

In: Minerva Anestesiologica, Vol. 70, No. 11, 11.2004, p. 753-761.

Research output: Contribution to journalArticle

Stoppa, F, Perrotta, D, Tomasello, C, Cecchetti, C, Marano, M, Pasotti, E, Barbieri, MA, Conti, G & Pirozzi, N 2004, 'Ridotte dosi infusione di remifentanyl per l'analgo-sedazione in neonati in ventilazione meccanica', Minerva Anestesiologica, vol. 70, no. 11, pp. 753-761.
Stoppa, F. ; Perrotta, D. ; Tomasello, C. ; Cecchetti, C. ; Marano, M. ; Pasotti, E. ; Barbieri, M. A. ; Conti, G. ; Pirozzi, N. / Ridotte dosi infusione di remifentanyl per l'analgo-sedazione in neonati in ventilazione meccanica. In: Minerva Anestesiologica. 2004 ; Vol. 70, No. 11. pp. 753-761.
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AU - Cecchetti, C.

AU - Marano, M.

AU - Pasotti, E.

AU - Barbieri, M. A.

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N2 - Aim. The aim of this study was to evaluate the analgesic effects of remifentanyl® on mechanically ventilated newborns. Methods. Eighteen newborns, mechanically ventilated, were submitted to continuous infusion of R. A pain scale was used to evaluate comfort during mechanical ventilation. Data were collected at T0, T1, Tn, T ext, T post-ext; statistical analysis was performed by Student's t test and Pearson coefficient. Results. Mean R infusion time was 66.94±22.24 h, with mean dose of R 0.146±0.038 γ/kg/min. Mean time to reach comfort was 20±13.11 h with a mean infusion of R equal to 0.173±0.146 γ/kg/min; R was 0.18±0.039 γ/kg/min on pressure controlled ventilation and R was 0.09± 0.045 γ/kg/min on assisted ventilation. Statistically significant was considered the decrease in HR as well as the increase of SpO2 at T0 vs 30 min after infusion. Conclusion. No adverse effects were observed during and after infusion.

AB - Aim. The aim of this study was to evaluate the analgesic effects of remifentanyl® on mechanically ventilated newborns. Methods. Eighteen newborns, mechanically ventilated, were submitted to continuous infusion of R. A pain scale was used to evaluate comfort during mechanical ventilation. Data were collected at T0, T1, Tn, T ext, T post-ext; statistical analysis was performed by Student's t test and Pearson coefficient. Results. Mean R infusion time was 66.94±22.24 h, with mean dose of R 0.146±0.038 γ/kg/min. Mean time to reach comfort was 20±13.11 h with a mean infusion of R equal to 0.173±0.146 γ/kg/min; R was 0.18±0.039 γ/kg/min on pressure controlled ventilation and R was 0.09± 0.045 γ/kg/min on assisted ventilation. Statistically significant was considered the decrease in HR as well as the increase of SpO2 at T0 vs 30 min after infusion. Conclusion. No adverse effects were observed during and after infusion.

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KW - Intensive care units, neonatal

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KW - Pain, diagnosis

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