Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major

Alberto G Ambrogio, Leila Danesi, Marina Baldini, Raffaella Radin, Elena Cassinerio, Giovanna Graziadei, Nadia Mirra, Emanuela D'Angelo, Alessia Marcon, Marta Mancarella, Alessandra Orsatti, Federico Bonetti, Massimo Scacchi, Maria Domenica Cappellini, Luca Persani, Francesca Pecori Giraldi

Research output: Contribution to journalArticlepeer-review


PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e.,
Original languageItalian
Pages (from-to)348-354
Number of pages7
Issue number2
Publication statusPublished - May 2018

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