Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major

Alberto G Ambrogio; Leila Danesi; Marina Baldini; Raffaella Radin; Elena Cassinerio; Giovanna Graziadei; Nadia Mirra; Emanuela D'Angelo; Alessia Marcon; Marta Mancarella; Alessandra Orsatti; Federico Bonetti; Massimo Scacchi; Maria Domenica Cappellini; Luca Persani; Francesca Pecori Giraldi

doi:10.1007/s12020-018-1562-z

Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major

Alberto G Ambrogio, Leila Danesi, Marina Baldini, Raffaella Radin, Elena Cassinerio, Giovanna Graziadei, Nadia Mirra, Emanuela D'Angelo, Alessia Marcon, Marta Mancarella, Alessandra Orsatti, Federico Bonetti, Massimo Scacchi, Maria Domenica Cappellini, Luca Persani, Francesca Pecori Giraldi

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e.,

Original language	Italian
Pages (from-to)	348-354
Number of pages	7
Journal	Endocrine
Volume	60
Issue number	2
DOIs	https://doi.org/10.1007/s12020-018-1562-z
Publication status	Published - May 2018

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Ambrogio, A. G., Danesi, L., Baldini, M., Radin, R., Cassinerio, E., Graziadei, G., Mirra, N., D'Angelo, E., Marcon, A., Mancarella, M., Orsatti, A., Bonetti, F., Scacchi, M., Cappellini, M. D., Persani, L., & Pecori Giraldi, F. (2018). Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major. Endocrine, 60(2), 348-354. https://doi.org/10.1007/s12020-018-1562-z

Ambrogio, AG, Danesi, L, Baldini, M, Radin, R, Cassinerio, E , Graziadei, G , Mirra, N , D'Angelo, E, Marcon, A, Mancarella, M, Orsatti, A, Bonetti, F , Scacchi, M , Cappellini, MD , Persani, L & Pecori Giraldi, F 2018, 'Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major', Endocrine, vol. 60, no. 2, pp. 348-354. https://doi.org/10.1007/s12020-018-1562-z

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title = "Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major",

abstract = "PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e., ",

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T1 - Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major

AU - Ambrogio, Alberto G

AU - Danesi, Leila

AU - Baldini, Marina

AU - Radin, Raffaella

AU - Cassinerio, Elena

AU - Graziadei, Giovanna

AU - Mirra, Nadia

AU - D'Angelo, Emanuela

AU - Marcon, Alessia

AU - Mancarella, Marta

AU - Orsatti, Alessandra

AU - Bonetti, Federico

AU - Scacchi, Massimo

AU - Cappellini, Maria Domenica

AU - Persani, Luca

AU - Pecori Giraldi, Francesca

PY - 2018/5

Y1 - 2018/5

N2 - PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e.,

AB - PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e.,

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KW - Adrenocorticotropic Hormone

KW - Adult

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Hydrocortisone/blood

KW - Italy/epidemiology

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Saliva/chemistry

KW - Young Adult

KW - beta-Thalassemia/complications

U2 - 10.1007/s12020-018-1562-z

DO - 10.1007/s12020-018-1562-z

M3 - Articolo

VL - 60

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JO - Endocrine

JF - Endocrine

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