Abstract
| Original language | Italian |
|---|---|
| Pages (from-to) | 348-354 |
| Number of pages | 7 |
| Journal | Endocrine |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - May 2018 |
Cite this
Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major. / Ambrogio, Alberto G; Danesi, Leila; Baldini, Marina; Radin, Raffaella; Cassinerio, Elena; Graziadei, Giovanna; Mirra, Nadia; D'Angelo, Emanuela; Marcon, Alessia; Mancarella, Marta; Orsatti, Alessandra; Bonetti, Federico; Scacchi, Massimo; Cappellini, Maria Domenica; Persani, Luca; Pecori Giraldi, Francesca.
In: Endocrine, Vol. 60, No. 2, 05.2018, p. 348-354.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major
AU - Ambrogio, Alberto G
AU - Danesi, Leila
AU - Baldini, Marina
AU - Radin, Raffaella
AU - Cassinerio, Elena
AU - Graziadei, Giovanna
AU - Mirra, Nadia
AU - D'Angelo, Emanuela
AU - Marcon, Alessia
AU - Mancarella, Marta
AU - Orsatti, Alessandra
AU - Bonetti, Federico
AU - Scacchi, Massimo
AU - Cappellini, Maria Domenica
AU - Persani, Luca
AU - Pecori Giraldi, Francesca
PY - 2018/5
Y1 - 2018/5
N2 - PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e.,
AB - PURPOSE: Beta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.METHODS: Cross-sectional study including 72 adults with β-thalassemia major. Patients were tested with 1 µg ACTH for serum and salivary cortisol.RESULTS: Subnormal serum cortisol responses to ACTH stimulation (i.e.,
KW - Adrenal Insufficiency/diagnosis
KW - Adrenocorticotropic Hormone
KW - Adult
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Hydrocortisone/blood
KW - Italy/epidemiology
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Saliva/chemistry
KW - Young Adult
KW - beta-Thalassemia/complications
U2 - 10.1007/s12020-018-1562-z
DO - 10.1007/s12020-018-1562-z
M3 - Articolo
VL - 60
SP - 348
EP - 354
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 2
ER -