Low-dose whey proteins supplementation can reduce oxidative stress in Cystic Fibrosis. A 36 months preliminary clinical trial

A. De Alessandri, L. Minicucci, R. Buzzetti, C. Zucchi, M. P. Ierardi, R. Casciaro, K. Perri, F. Cresta, E. L. Iorio

Research output: Contribution to journalArticle

Abstract

Cystic Fibrosis (CF) is the most common lethal autosomal-recessive disorder in the Caucasian population.The pulmonary disease is the most relevant clinical expression of CF. Cystic fibrosis airways are under the effect of oxidants that are generated from increased inflammation and infections present in the lungs. Low glutathione (GSH) levels in epithelial lining fluid and neutrophils/blood plasma can impair antioxidant defences thus magnifying the oxidative stress in patients suffering from CF. On these basis increasing or restoring normal GSH levels has been proposed as a potentially useful strategy in CF. Cow's milk whey proteins because its high levels of cysteine and cystine, that are both precursors of endogenous GSH synthesis, can increase tissue levels of GSH as required in CF.Therefore the primary aim of this study was to evaluate the efficacy of a diet supplementation with a cow's milk whey protein formula (WPF) on oxidative stress in CF patients. The secondary goal was to assess the effects of this supplementation on clinical status and its tolerability. This is a prospective, open, clinical study conducted among CF patients in regular follow up at CF Centre of Genova, Italy in the period 2007-2010. Participants received whey proteins with WPF, which was administered orally once a day. This study deals with 59 patients.Mean follow up period was 18 months (range 3-36).Oxidative balance was evaluated as BAP test and d-ROMs test while improvement of respiratory function was assessed as FEV1% predicted for sex and age. In our data stress oxidative status showed to be favourably influenced byWPF administration as a matter of fact mean BAP value increased, even if in a not significantly way and,mainly, the d-ROMs value significantly decreased after WPF intake. Unfortunately stress oxidative condition in our data is not really associated with clinical status improvement. Conclusively we can say that, a nutraceutical formula, as WPF, has demonstrated a real effect on improvement oxidative stress in CF patients and is well accepted and well tolerated.

Original languageEnglish
Pages (from-to)71-80
Number of pages10
JournalProgress in Nutrition
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 2011

Keywords

  • BAP test
  • Cystic Fibrosis
  • d-ROMs test
  • GSH
  • Oxidative stress
  • Whey protein

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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    De Alessandri, A., Minicucci, L., Buzzetti, R., Zucchi, C., Ierardi, M. P., Casciaro, R., Perri, K., Cresta, F., & Iorio, E. L. (2011). Low-dose whey proteins supplementation can reduce oxidative stress in Cystic Fibrosis. A 36 months preliminary clinical trial. Progress in Nutrition, 13(SUPPL. 1), 71-80.