Low duplicability and network fragility of cancer genes

Davide Rambaldi, Federico M. Giorgi, Fabrizio Capuani, Andrea Ciliberto, Francesca D. Ciccarelli

Research output: Contribution to journalArticlepeer-review

Abstract

We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalTrends in Genetics
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2008

ASJC Scopus subject areas

  • Genetics

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