Low duplicability and network fragility of cancer genes

Davide Rambaldi; Federico M. Giorgi; Fabrizio Capuani; Andrea Ciliberto; Francesca D. Ciccarelli

doi:10.1016/j.tig.2008.06.003

Low duplicability and network fragility of cancer genes

Davide Rambaldi, Federico M. Giorgi, Fabrizio Capuani, Andrea Ciliberto, Francesca D. Ciccarelli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.

Original language	English
Pages (from-to)	427-430
Number of pages	4
Journal	Trends in Genetics
Volume	24
Issue number	9
DOIs	https://doi.org/10.1016/j.tig.2008.06.003
Publication status	Published - Sep 2008

ASJC Scopus subject areas

Genetics

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abstract = "We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.",

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