TY - JOUR
T1 - Low duplicability and network fragility of cancer genes
AU - Rambaldi, Davide
AU - Giorgi, Federico M.
AU - Capuani, Fabrizio
AU - Ciliberto, Andrea
AU - Ciccarelli, Francesca D.
PY - 2008/9
Y1 - 2008/9
N2 - We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.
AB - We identified genomic and network properties of ∼600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.
UR - http://www.scopus.com/inward/record.url?scp=49849100187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49849100187&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2008.06.003
DO - 10.1016/j.tig.2008.06.003
M3 - Article
C2 - 18675489
AN - SCOPUS:49849100187
VL - 24
SP - 427
EP - 430
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 9
ER -