Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients

Paola Costa, Stefano Rusconi, Manuela Foglia, Domenico Mavilio, Giuseppe Murdaca, Francesco Puppo, Maria Cristina Mingari, Massimo Galli, Lorenzo Moretta, Andrea De Maria

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Abstract

We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mono-nuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalAIDS (London, England)
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 24 2003

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HIV Long-Term Survivors
KIR Receptors
Cytotoxic T-Lymphocytes
HIV-1
HIV Infections
Tissue Donors
Viruses

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients. / Costa, Paola; Rusconi, Stefano; Foglia, Manuela; Mavilio, Domenico; Murdaca, Giuseppe; Puppo, Francesco; Mingari, Maria Cristina; Galli, Massimo; Moretta, Lorenzo; De Maria, Andrea.

In: AIDS (London, England), Vol. 17, No. 2, 24.01.2003, p. 257-260.

Research output: Contribution to journalArticle

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AU - Murdaca, Giuseppe

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AU - Moretta, Lorenzo

AU - De Maria, Andrea

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