Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier

Gemma Lombardi, Valentina Berti, Andrea Tedde, Silvia Bagnoli, Irene Piaceri, Cristina Polito, Giulia Lucidi, Camilla Ferrari, Andrea Ginestroni, Marco Moretti, Alberto Pupi, Benedetta Nacmias, Sandro Sorbi

Research output: Contribution to journalArticle

Abstract

According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only incidental.

Original languageEnglish
Pages (from-to)697-703
Number of pages7
JournalJournal of Alzheimer's Disease
Volume57
Issue number3
DOIs
Publication statusPublished - 2017

Keywords

  • APP Ala713Thr
  • familial Alzheimer's disease
  • florbetapir PET
  • frontotemporal dementia

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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    Lombardi, G., Berti, V., Tedde, A., Bagnoli, S., Piaceri, I., Polito, C., Lucidi, G., Ferrari, C., Ginestroni, A., Moretti, M., Pupi, A., Nacmias, B., & Sorbi, S. (2017). Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier. Journal of Alzheimer's Disease, 57(3), 697-703. https://doi.org/10.3233/JAD-161170