Low formation of nitric oxide in polymorphonuclear cells in unstable angina pectoris

Vincenzo Mollace, Francesco Romeo, Eugenio Martuscelli, Giuseppe M C Rosano, Giorgio Federici, Giuseppe Nisticó, Benedetto Marino

Research output: Contribution to journalArticle

Abstract

In conclusion, these data demonstrate that a decreased ability to synthesize and release NO may occur in polymorphonuclear cells of a selected group of young patients with unstable angina pectoris. Further evidence is required to assess whether this could account for a more generalized deficiency in the mechanisms, maintaining vascular endothelium into an antiadhesive and vasodilating state, that involve NO release. However, detection of NO generation in circulating cells, such as polymorphonuclear cells, may represent a novel and potentially useful approach in evaluating the possible role of the L-arginine-NO pathway in the pathophysiology of severe coronary artery disease.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalThe American Journal of Cardiology
Volume74
Issue number1
DOIs
Publication statusPublished - Jul 1 1994

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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