Low frequency component in systolic arterial pressure variability in patients with persistent atrial fibrillation

Luca Mainardi, Valentina Corino, Sebastiano Belletti, Paolo Terranova, Federico Lombardi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Atrial fibrillation (AF) is a common arrhythmia characterized by irregular ventricular response. During AF, beat-to-beat variability of arterial pressure (AP) is increased because of continuous changes in filling time, stroke volume and contractility. Only a few studies have analyzed short-term AP variability during AF but they were mainly focused on the effects of respiration. We therefore analyzed short-term systolic (S), diastolic (D) and mean (M) AP variability by autoregressive method and an FFT-based spectral estimation (Welch periodogram) in 26 patients with persistent AF before and after restoration of sinus rhythm by electrical cardioversion. A low frequency (LF) component (central frequency 0.07 ± 0.02 Hz, mean ± standard deviation) of SAP variability was observed in 23 out of 26 patients during AF. Frequency analysis of DAP and MAP also showed a LF component with a central frequency of 0.08 ± 0.03 Hz (20 patients) and 0.07 ± 0.03 Hz (25 patients), respectively. After recovery of sinus rhythm, we found significant reduction in mean SAP, DAP and MAP variability in all frequency bands. Squared coherence between SAP and heart rate variability after recovery of sinus rhythm revealed a weak and strong coupling within, respectively, LF and HF frequency bands. These data indicate that in patients with AF, in spite of an absence of rhythmical oscillation in RR interval time series, it is possible to observe a LF component in SAP, DAP and MAP variability signals. These 0.1 Hz fluctuations reflect the influence of the sympathetic fibres acting on the cardiovascular system.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalAutonomic Neuroscience: Basic and Clinical
Volume151
Issue number2
DOIs
Publication statusPublished - Dec 3 2009

Fingerprint

Atrial Fibrillation
Arterial Pressure
Blood Pressure
Adrenergic Fibers
Electric Countershock
Cardiovascular System
Stroke Volume
Cardiac Arrhythmias
Respiration
Heart Rate

Keywords

  • Arterial pressure variability
  • Autoregressive spectral analysis
  • Baroreflex mechanisms
  • Electrical cardioversion
  • Rhythmical oscillations

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Low frequency component in systolic arterial pressure variability in patients with persistent atrial fibrillation. / Mainardi, Luca; Corino, Valentina; Belletti, Sebastiano; Terranova, Paolo; Lombardi, Federico.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 151, No. 2, 03.12.2009, p. 147-153.

Research output: Contribution to journalArticle

Mainardi, Luca ; Corino, Valentina ; Belletti, Sebastiano ; Terranova, Paolo ; Lombardi, Federico. / Low frequency component in systolic arterial pressure variability in patients with persistent atrial fibrillation. In: Autonomic Neuroscience: Basic and Clinical. 2009 ; Vol. 151, No. 2. pp. 147-153.
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