Low-frequency positive pressure ventilation with extracorporeal carbon dioxide removal (LFPPV-ECCO 2R): An experimental study

L. Gattinoni, T. Kolobow, T. Tomlinson, G. Iapichino, M. Samaja, D. White, J. Pierce

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe a new form of mechanical pulmonary ventilation, low-frequency positive pressure ventilation with extracorporeal CO 2 removal (LFPPV-ECCO 2R). In a series of animal studies the rate of mechanical ventilation was 0.66, 1, 2, and 4 min -1 at a tidal volume of 3, 10, and 15 ml kg -1. It was possible to maintain normal blood gases and normal lung volumes and lung mechanics even at the lowest ventilator rate with tidal volumes of 10 or 15 ml kg -1. Each experiment lasted 7 hr.

Original languageEnglish
Pages (from-to)470-477
Number of pages8
JournalAnesthesia and Analgesia
Volume57
Issue number4
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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