Low frequency spectral component of heart rate variability and myocardial beta-adrenoceptor density after acute myocardial infarction

Stefano Guzzetti, Nicos Spyrou, Stuart D. Rosen, Silvia Mezzetti, Elena Martinoli, Rodney A. Foale, Paolo G. Camici

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The low frequency spectral component (LF; 0.04-0.15 Hz) of heart rate variability (HRV) is considered to be an index of sympathetic modulation of sinus node activity under physiological conditions, although the relationship is less clearly defined in non-physiological conditions. Several cardiovascular diseases are characterized by an absent or blunted 24-h pattern of the LF spectral component. The aim of the present study was to investigate the relationship between chronically increased neural sympathetic efferent drive to the heart, quantified in terms of downregulation of myocardial β-receptors, and the 24-h power of the LF spectral component in patients after acute myocardial infarction. Methods: In 24 patients, HRV was analyzed for a 24-h period, one month after an uncomplicated Q wave myocardial infarction. The following time domain measures and spectral components were calculated: mean RR, SDNN, SDANN, RMSSD, SDNN index, pNN50, and very low frequency (VLF), low frequency (LF) and high frequency (HF) spectral components. The density of β-adrenoceptors was measured in vivo by positron emission tomography (PET) with 11C-CGP-12177. Results: Post-AMI patients had normal plasma levels of adrenaline and noradrenaline (respectively 1.48 ± 0.18 and 0.28 ± 0.03 IU/L) but reduced myocardial β-adrenoceptor density (6.86 ± 0.24 pmol/g). Patients had similar heart rates but lower values of SDNN and SDANN compared with control subjects. The absolute and normalized power of the spectral components were similar in the two groups, but the usual day-night oscillation was blunted in patients. Moreover, the day-night change in the power of the LF spectral component was positively related (r = 0.51; p <0.001) to the myocardial β-adrenoceptor density. Conclusions: The loss of the day-night oscillation of the LF spectral component appears to be a significant marker of sustained sympathetic over-activity in post-AMI patients.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalBasic Research in Cardiology
Volume97
Issue number1
DOIs
Publication statusPublished - 2002

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Adrenergic Receptors
Heart Rate
Myocardial Infarction
Sinoatrial Node
Positron-Emission Tomography
Epinephrine
Norepinephrine
Cardiovascular Diseases
Down-Regulation

Keywords

  • Autonomic nervous system
  • Heart rate variability
  • Myocardial infarction
  • Neurotransmitters
  • Receptors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Low frequency spectral component of heart rate variability and myocardial beta-adrenoceptor density after acute myocardial infarction. / Guzzetti, Stefano; Spyrou, Nicos; Rosen, Stuart D.; Mezzetti, Silvia; Martinoli, Elena; Foale, Rodney A.; Camici, Paolo G.

In: Basic Research in Cardiology, Vol. 97, No. 1, 2002, p. 97-104.

Research output: Contribution to journalArticle

Guzzetti, Stefano ; Spyrou, Nicos ; Rosen, Stuart D. ; Mezzetti, Silvia ; Martinoli, Elena ; Foale, Rodney A. ; Camici, Paolo G. / Low frequency spectral component of heart rate variability and myocardial beta-adrenoceptor density after acute myocardial infarction. In: Basic Research in Cardiology. 2002 ; Vol. 97, No. 1. pp. 97-104.
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T1 - Low frequency spectral component of heart rate variability and myocardial beta-adrenoceptor density after acute myocardial infarction

AU - Guzzetti, Stefano

AU - Spyrou, Nicos

AU - Rosen, Stuart D.

AU - Mezzetti, Silvia

AU - Martinoli, Elena

AU - Foale, Rodney A.

AU - Camici, Paolo G.

PY - 2002

Y1 - 2002

N2 - Objective: The low frequency spectral component (LF; 0.04-0.15 Hz) of heart rate variability (HRV) is considered to be an index of sympathetic modulation of sinus node activity under physiological conditions, although the relationship is less clearly defined in non-physiological conditions. Several cardiovascular diseases are characterized by an absent or blunted 24-h pattern of the LF spectral component. The aim of the present study was to investigate the relationship between chronically increased neural sympathetic efferent drive to the heart, quantified in terms of downregulation of myocardial β-receptors, and the 24-h power of the LF spectral component in patients after acute myocardial infarction. Methods: In 24 patients, HRV was analyzed for a 24-h period, one month after an uncomplicated Q wave myocardial infarction. The following time domain measures and spectral components were calculated: mean RR, SDNN, SDANN, RMSSD, SDNN index, pNN50, and very low frequency (VLF), low frequency (LF) and high frequency (HF) spectral components. The density of β-adrenoceptors was measured in vivo by positron emission tomography (PET) with 11C-CGP-12177. Results: Post-AMI patients had normal plasma levels of adrenaline and noradrenaline (respectively 1.48 ± 0.18 and 0.28 ± 0.03 IU/L) but reduced myocardial β-adrenoceptor density (6.86 ± 0.24 pmol/g). Patients had similar heart rates but lower values of SDNN and SDANN compared with control subjects. The absolute and normalized power of the spectral components were similar in the two groups, but the usual day-night oscillation was blunted in patients. Moreover, the day-night change in the power of the LF spectral component was positively related (r = 0.51; p <0.001) to the myocardial β-adrenoceptor density. Conclusions: The loss of the day-night oscillation of the LF spectral component appears to be a significant marker of sustained sympathetic over-activity in post-AMI patients.

AB - Objective: The low frequency spectral component (LF; 0.04-0.15 Hz) of heart rate variability (HRV) is considered to be an index of sympathetic modulation of sinus node activity under physiological conditions, although the relationship is less clearly defined in non-physiological conditions. Several cardiovascular diseases are characterized by an absent or blunted 24-h pattern of the LF spectral component. The aim of the present study was to investigate the relationship between chronically increased neural sympathetic efferent drive to the heart, quantified in terms of downregulation of myocardial β-receptors, and the 24-h power of the LF spectral component in patients after acute myocardial infarction. Methods: In 24 patients, HRV was analyzed for a 24-h period, one month after an uncomplicated Q wave myocardial infarction. The following time domain measures and spectral components were calculated: mean RR, SDNN, SDANN, RMSSD, SDNN index, pNN50, and very low frequency (VLF), low frequency (LF) and high frequency (HF) spectral components. The density of β-adrenoceptors was measured in vivo by positron emission tomography (PET) with 11C-CGP-12177. Results: Post-AMI patients had normal plasma levels of adrenaline and noradrenaline (respectively 1.48 ± 0.18 and 0.28 ± 0.03 IU/L) but reduced myocardial β-adrenoceptor density (6.86 ± 0.24 pmol/g). Patients had similar heart rates but lower values of SDNN and SDANN compared with control subjects. The absolute and normalized power of the spectral components were similar in the two groups, but the usual day-night oscillation was blunted in patients. Moreover, the day-night change in the power of the LF spectral component was positively related (r = 0.51; p <0.001) to the myocardial β-adrenoceptor density. Conclusions: The loss of the day-night oscillation of the LF spectral component appears to be a significant marker of sustained sympathetic over-activity in post-AMI patients.

KW - Autonomic nervous system

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KW - Myocardial infarction

KW - Neurotransmitters

KW - Receptors

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