Low frequency stimulation of the nucleus tegmenti pedunculopontini increases cortical metabolism in Parkinsonian patients

R. Ceravolo, L. Brusa, S. Galati, D. Volterrani, A. Peppe, G. Siciliano, M. Pierantozzi, V. Moschella, U. Bonuccelli, P. Stanzione, A. Stefani

Research output: Contribution to journalArticlepeer-review

Abstract

Background and purpose: To evaluate the effects of 25-Hz deep brain stimulation of the nucleus tegmenti pedunculopontini (PPTg) on brain metabolic activity. Methods: Six patients with Parkinson's disease (PD) who had bilateral stereotactic implantation of PPTg at least 12months prior to evaluation were included in our study. All underwent, in separate sessions, 18-FDG-PET in core assessment programme for intra-cerebral transplantation as well as motor evaluation [Unified Parkinson's disease rating scale (UPDRS) - section III] and a battery of cognitive testing. Results: PPTg-ON (low bipolar contacts, 25Hz) promoted a significant increase of glucose utilization in bilateral prefrontal areas including dorsolateral prefrontal cortex (DLPFC, BA9), orbito-frontal cortex (BA47), anterior cingulate (BA 25-32), superior frontal gyrus (BA 10) and supramarginal gyrus (BA40); a significant increase of uptake and consumption of FDG also occurred in the left ventral striatum, left subgyral (BA 46), right insula (BA 13) and right superior temporal gyrus (BA 22). PPTg-ON was associated with a significant decrease of glucose utilization in the left cerebellar anterior lobe (culmen) and right cerebellar posterior lobe (declive). In the same patients, PPTg-ON improved delayed recall (P

Original languageEnglish
Pages (from-to)842-849
Number of pages8
JournalEuropean Journal of Neurology
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Deep brain stimulation
  • Executive functions
  • FDG-PET
  • PPN

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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