Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease

A. Priori, G. Ardolino, S. Marceglia, S. Mrakic-Sposta, M. Locatelli, F. Tamma, L. Rossi, G. Foffani

Research output: Contribution to journalArticle

Abstract

This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change = 0.93 ± 0.62; Wilcoxon: p = 0.0002, n = 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalBrain Research Bulletin
Volume71
Issue number1-3
DOIs
Publication statusPublished - Dec 11 2006

Fingerprint

Deep Brain Stimulation
Parkinson Disease
Subthalamic Nucleus
Implanted Electrodes
Electrodes
Brain

Keywords

  • Basal ganglia
  • DBS
  • Human
  • LFPs
  • Local field potentials
  • Parkinson's disease
  • STN
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease. / Priori, A.; Ardolino, G.; Marceglia, S.; Mrakic-Sposta, S.; Locatelli, M.; Tamma, F.; Rossi, L.; Foffani, G.

In: Brain Research Bulletin, Vol. 71, No. 1-3, 11.12.2006, p. 149-154.

Research output: Contribution to journalArticle

Priori, A. ; Ardolino, G. ; Marceglia, S. ; Mrakic-Sposta, S. ; Locatelli, M. ; Tamma, F. ; Rossi, L. ; Foffani, G. / Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease. In: Brain Research Bulletin. 2006 ; Vol. 71, No. 1-3. pp. 149-154.
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