Abstract
Elderly patients with chronic hepatitis C have a reduced responsiveness to antiviral therapy with Peg-interferon and ribavirin. The dose reduction or the discontinuation of ribavirin due to the occurrence of anaemia is one of the most important causes for the low sustained viral response observed in older patients. We aimed to evaluate the relationship between baseline renal function and the early onset of ribavirin-associated anaemia in older (≤yen;60 years) patients. Using data from 348 patients with chronic hepatitis C consecutively treated with peg-interferon plus ribavirin, we investigated which factors were associated with the occurrence of anaemia in elderly patients (≤yen;60 years). Ribavirin-induced anaemia occurred in 40.5% of patients. Older patients showed a rate of anaemia significantly higher than younger patients (51.5% vs 36.3%; P = 0.009). Consequently, the rate of ribavirin dose reduction or discontinuation due to anaemia was 35.1% in older patients and 23.5% in younger patients (P = 0.029). A significantly higher proportion of older patients had a low baseline glomerular filtration rate (GFR) compared with younger patients (56.7% vs 27.1%; P <0.001). At the multivariate regression analysis, low baseline GFR (60 years, a low pre-treatment GFR was strongly associated with the risk to develop ribavirin-related anaemia with consequent reduction in ribavirin doses.
| Original language | English |
|---|---|
| Journal | Journal of Viral Hepatitis |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2013 |
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Keywords
- age
- anaemia
- chronic hepatitis C
- renal function
- ribavirin
- treatment
ASJC Scopus subject areas
- Hepatology
- Infectious Diseases
- Virology
Cite this
Low glomerular filtration rate is a risk factor for ribavirin-associated anaemia in old patients with chronic hepatitis C. / Borroni, G.; Cazzaniga, M.; Andreoletti, M.; Ceriani, R.; Guerzoni, P.; Omazzi, B.; Pich, M. G L; Prada, A.; Spinzi, G.; Terreni, N.; Salerno, F.
In: Journal of Viral Hepatitis, Vol. 20, No. 4, 04.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low glomerular filtration rate is a risk factor for ribavirin-associated anaemia in old patients with chronic hepatitis C
AU - Borroni, G.
AU - Cazzaniga, M.
AU - Andreoletti, M.
AU - Ceriani, R.
AU - Guerzoni, P.
AU - Omazzi, B.
AU - Pich, M. G L
AU - Prada, A.
AU - Spinzi, G.
AU - Terreni, N.
AU - Salerno, F.
PY - 2013/4
Y1 - 2013/4
N2 - Elderly patients with chronic hepatitis C have a reduced responsiveness to antiviral therapy with Peg-interferon and ribavirin. The dose reduction or the discontinuation of ribavirin due to the occurrence of anaemia is one of the most important causes for the low sustained viral response observed in older patients. We aimed to evaluate the relationship between baseline renal function and the early onset of ribavirin-associated anaemia in older (≤yen;60 years) patients. Using data from 348 patients with chronic hepatitis C consecutively treated with peg-interferon plus ribavirin, we investigated which factors were associated with the occurrence of anaemia in elderly patients (≤yen;60 years). Ribavirin-induced anaemia occurred in 40.5% of patients. Older patients showed a rate of anaemia significantly higher than younger patients (51.5% vs 36.3%; P = 0.009). Consequently, the rate of ribavirin dose reduction or discontinuation due to anaemia was 35.1% in older patients and 23.5% in younger patients (P = 0.029). A significantly higher proportion of older patients had a low baseline glomerular filtration rate (GFR) compared with younger patients (56.7% vs 27.1%; P <0.001). At the multivariate regression analysis, low baseline GFR (60 years, a low pre-treatment GFR was strongly associated with the risk to develop ribavirin-related anaemia with consequent reduction in ribavirin doses.
AB - Elderly patients with chronic hepatitis C have a reduced responsiveness to antiviral therapy with Peg-interferon and ribavirin. The dose reduction or the discontinuation of ribavirin due to the occurrence of anaemia is one of the most important causes for the low sustained viral response observed in older patients. We aimed to evaluate the relationship between baseline renal function and the early onset of ribavirin-associated anaemia in older (≤yen;60 years) patients. Using data from 348 patients with chronic hepatitis C consecutively treated with peg-interferon plus ribavirin, we investigated which factors were associated with the occurrence of anaemia in elderly patients (≤yen;60 years). Ribavirin-induced anaemia occurred in 40.5% of patients. Older patients showed a rate of anaemia significantly higher than younger patients (51.5% vs 36.3%; P = 0.009). Consequently, the rate of ribavirin dose reduction or discontinuation due to anaemia was 35.1% in older patients and 23.5% in younger patients (P = 0.029). A significantly higher proportion of older patients had a low baseline glomerular filtration rate (GFR) compared with younger patients (56.7% vs 27.1%; P <0.001). At the multivariate regression analysis, low baseline GFR (60 years, a low pre-treatment GFR was strongly associated with the risk to develop ribavirin-related anaemia with consequent reduction in ribavirin doses.
KW - age
KW - anaemia
KW - chronic hepatitis C
KW - renal function
KW - ribavirin
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=84875227887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875227887&partnerID=8YFLogxK
U2 - 10.1111/jvh.12015
DO - 10.1111/jvh.12015
M3 - Article
C2 - 23490395
AN - SCOPUS:84875227887
VL - 20
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
SN - 1352-0504
IS - 4
ER -