Low glomerular filtration rate is a risk factor for ribavirin-associated anaemia in old patients with chronic hepatitis C

G. Borroni, M. Cazzaniga, M. Andreoletti, R. Ceriani, P. Guerzoni, B. Omazzi, M. G L Pich, A. Prada, G. Spinzi, N. Terreni, F. Salerno

Research output: Contribution to journalArticle

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Abstract

Elderly patients with chronic hepatitis C have a reduced responsiveness to antiviral therapy with Peg-interferon and ribavirin. The dose reduction or the discontinuation of ribavirin due to the occurrence of anaemia is one of the most important causes for the low sustained viral response observed in older patients. We aimed to evaluate the relationship between baseline renal function and the early onset of ribavirin-associated anaemia in older (≤yen;60 years) patients. Using data from 348 patients with chronic hepatitis C consecutively treated with peg-interferon plus ribavirin, we investigated which factors were associated with the occurrence of anaemia in elderly patients (≤yen;60 years). Ribavirin-induced anaemia occurred in 40.5% of patients. Older patients showed a rate of anaemia significantly higher than younger patients (51.5% vs 36.3%; P = 0.009). Consequently, the rate of ribavirin dose reduction or discontinuation due to anaemia was 35.1% in older patients and 23.5% in younger patients (P = 0.029). A significantly higher proportion of older patients had a low baseline glomerular filtration rate (GFR) compared with younger patients (56.7% vs 27.1%; P <0.001). At the multivariate regression analysis, low baseline GFR (60 years, a low pre-treatment GFR was strongly associated with the risk to develop ribavirin-related anaemia with consequent reduction in ribavirin doses.

Original languageEnglish
JournalJournal of Viral Hepatitis
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Ribavirin
Chronic Hepatitis C
Glomerular Filtration Rate
Anemia
Interferons
Antiviral Agents
Multivariate Analysis
Regression Analysis

Keywords

  • age
  • anaemia
  • chronic hepatitis C
  • renal function
  • ribavirin
  • treatment

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases
  • Virology

Cite this

Low glomerular filtration rate is a risk factor for ribavirin-associated anaemia in old patients with chronic hepatitis C. / Borroni, G.; Cazzaniga, M.; Andreoletti, M.; Ceriani, R.; Guerzoni, P.; Omazzi, B.; Pich, M. G L; Prada, A.; Spinzi, G.; Terreni, N.; Salerno, F.

In: Journal of Viral Hepatitis, Vol. 20, No. 4, 04.2013.

Research output: Contribution to journalArticle

Borroni, G, Cazzaniga, M, Andreoletti, M, Ceriani, R, Guerzoni, P, Omazzi, B, Pich, MGL, Prada, A, Spinzi, G, Terreni, N & Salerno, F 2013, 'Low glomerular filtration rate is a risk factor for ribavirin-associated anaemia in old patients with chronic hepatitis C', Journal of Viral Hepatitis, vol. 20, no. 4. https://doi.org/10.1111/jvh.12015
Borroni, G. ; Cazzaniga, M. ; Andreoletti, M. ; Ceriani, R. ; Guerzoni, P. ; Omazzi, B. ; Pich, M. G L ; Prada, A. ; Spinzi, G. ; Terreni, N. ; Salerno, F. / Low glomerular filtration rate is a risk factor for ribavirin-associated anaemia in old patients with chronic hepatitis C. In: Journal of Viral Hepatitis. 2013 ; Vol. 20, No. 4.
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