Low-grade endotoxemia and clotting activation in the early phase of pneumonia

Roberto Cangemi, Patrizia Della Valle, Camilla Calvieri, G. Taliani, Patrizia Ferroni, M. Falcone, R. Carnevale, S. Bartimoccia, Armando D'Angelo, F. Violi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and objective: Community-acquired pneumonia (CAP) is associated with an increased risk of arterial and venous thrombosis but the underlying pathophysiological mechanisms are still unclear. We investigated if, in patients with CAP, a pro-thrombotic state does exist and its relationship with serum levels of endotoxins. Methods: A total of 104 consecutive patients with CAP were prospectively recruited and followed up until discharge. At admission and at discharge, serum endotoxins, systemic markers of clotting activation and zonulin, a marker of gut permeability, were analysed. Hospitalized patients matched for gender, age and comorbidities but without infections were used as control. Results: At admission, CAP patients showed higher plasma levels of F1 +2, a marker of thrombin generation (P=0.023), and lower levels of protein C (PC; P1 +2 significantly decreased (P

Original languageEnglish
JournalRespirology
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • Endotoxin
  • Pneumonia
  • Protein C
  • Thrombosis
  • Zonulin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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