Low-grade fibromatosis-like spindle cell metaplastic carcinoma: A basal-like tumor with a favorable clinical outcome. Report of two cases

Michele Podetta, Gioacchino D'Ambrosio, Alberta Ferrari, Adele Sgarella, Barbara Dal Bello, Gian Silvio Fossati, Sandro Zonta, Enrico Silini, Paolo Dionig

Research output: Contribution to journalArticle

Abstract

Fibromatosis-like spindle-cell metaplastic carcinoma (FLSpCQ is an atypical variant of spindle-cell carcinoma with a particular clinical behavior characterized by frequent local recurrence, very low potential for axillary lymph node metastasis, and uncommon distant metastases. Although it presents the typical immunoprofile of basal-like carcinomas, FLSpCC is associated with a favorable clinical outcome and conservative treatment is generally indicated. Because of the lack of specific clinical and radiological characteristics, the criteria for the differential diagnosis from other benign and malignant tumors are based only on histological findings and immunostaining. We report on two FLSpCC patients treated with wide local excision and mastectomy associated with axillary lymph node dissection. Although the biological behavior of this subtype of breast cancer has not been adequately evaluated, wide local excision or mastectomy with clear resection margins but no axillary dissection appears to be an adequate treatment approach.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalTumori
Volume95
Issue number2
Publication statusPublished - Mar 2009

Keywords

  • Basal-like carcinomas
  • Breast tumor
  • Fibromatosis
  • Metaplastic carcinoma
  • Spincre-cei carcinorra

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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