Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)

A multifocal disease

A. C. Wotherspoon, C. Doglioni, P. G. Isaacson

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Gastrectomy specimens from five patients following gastroscopic biopsies which showed low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) were examined by serially sectioning and paraffin wax embedding using a 'swiss roll' technique. This procedure allowed the construction of a map of the specimen on which the distribution of the lymphoma could be plotted. In each case confluent lymphoma was identified. In addition small foci of lymphoma consisting of 1-4 lymphoid follicles surrounded by neoplastic centrocyte-like cells were seen. The positions of these 'micro-lymphomas' were plotted on the gastrectomy maps, showing multiple foci distributed throughout the gastric mucosa. The identification of these microscopic lesions may explain the development of local relapse, often after a long disease-free interval, in patients with gastric MALT lymphoma treated by partial gastrectomy where excision appears to have been complete. Patients treated in this way should, therefore, be followed-up indefinitely, with regular endoscopy and gastric biopsy, in order to identify early local disease relapse.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalHistopathology
Volume20
Issue number1
Publication statusPublished - 1992

Fingerprint

Marginal Zone B-Cell Lymphoma
B-Cell Lymphoma
Lymphoma
Stomach
Gastrectomy
Gastric Mucosa
Paraffin Embedding
Biopsy
Recurrence
Waxes
Non-Hodgkin's Lymphoma
Endoscopy

Keywords

  • gastric lymphoma
  • MALT
  • mucosa-associated lymphoid tissue
  • multifocal disease

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) : A multifocal disease. / Wotherspoon, A. C.; Doglioni, C.; Isaacson, P. G.

In: Histopathology, Vol. 20, No. 1, 1992, p. 29-34.

Research output: Contribution to journalArticle

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