Low-Grade Papillary Schneiderian Carcinoma: Report of a Case with Molecular Characterization

Sergio Carnevale, Giuseppina Ferrario, Fabio Sovardi, Marco Benazzo, Patrizia Morbini

Research output: Contribution to journalArticlepeer-review


In 2015, Lewis et al. first described low-grade papillary Scheneiderian carcinoma (LGPSC) of the sinonasal tract. Their case resembled a sinonasal papilloma clinically and histopathologically; however, invasion and metastasis resulted in the death of the patient despite absence of malignant cytologic features. Additional reports established LGPSC as a distinct entity and characterized its immunohistochemical profile. Diffuse expression of low molecular weight cytokeratins, positivity for p16 and p53 in at least 50% of cells, a high Ki-67 index, and absence of human papillomavirus (HPV)-DNA was observed across all reported cases. We report an additional case of LGPSC and describe the clinical, histologic, and immunohistochemical features. In contrast to sinonasal papillomas, the case was negative for HPV-DNA and showed no mutations in the EGFR and KRAS hotspot regions.

Original languageEnglish
JournalHead and Neck Pathology
Publication statusAccepted/In press - Jan 1 2019


  • Inverted papilloma
  • Schneiderian papilloma
  • Sinonasal epithelium
  • Sinonasal papillary carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology


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