"Low-grade positivity" of HPV viral load after atypical squamous cells of undetermined significance (ASC-US) cytology identifies women at low-risk for cervical intraepithelial neoplasia grade 2 and 3

M. Origoni, G. Carminati, M. Sideri, M. Clementi, S. Rolla, M. Candiani

Research output: Contribution to journalArticle

Abstract

The correlation between high-risk HPV-DNA viral load, expressed as relative light units (RLU) values obtained from the Hybrid Capture 2 (HC2) test, and the prevalence of CIN2/CIN3 was investigated and statistically analyzed in 614 ASC-US consecutive cases. Cases were categorized into three groups according to RLU values: "low-grade positivity", "intermediate positivity" and "high-grade positivity", and the prevalence of CIN2/CIN3 was evaluated in the single groups and compared among them. CIN/CIN3 rates demonstrated a significant (p <0.001) increase with a direct correlation with increasing RLU values: 4.6% (RLU from 1.0 to 10.0), 9.1% (RLU from 11.0 to 100.0) and 32.2% (RLU > 100.0) respectively. The prevalence of CIN2/CIN3 between the group with RLU <10.0 (4.6%) and the group with RLU > 10 (24.2%) showed statistical significance (p = 0.0002). Increasing hrHPV viral load significantly correlates with increasing prevalence of CIN2/CIN3 in ASC-US cases.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume33
Issue number3
Publication statusPublished - 2012

Keywords

  • ASC-US
  • Cervical intraepithelial neoplasia
  • CIN
  • HC2
  • HPV
  • HPV-DNA
  • Viral load

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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