Abstract
The correlation between high-risk HPV-DNA viral load, expressed as relative light units (RLU) values obtained from the Hybrid Capture 2 (HC2) test, and the prevalence of CIN2/CIN3 was investigated and statistically analyzed in 614 ASC-US consecutive cases. Cases were categorized into three groups according to RLU values: "low-grade positivity", "intermediate positivity" and "high-grade positivity", and the prevalence of CIN2/CIN3 was evaluated in the single groups and compared among them. CIN/CIN3 rates demonstrated a significant (p <0.001) increase with a direct correlation with increasing RLU values: 4.6% (RLU from 1.0 to 10.0), 9.1% (RLU from 11.0 to 100.0) and 32.2% (RLU > 100.0) respectively. The prevalence of CIN2/CIN3 between the group with RLU <10.0 (4.6%) and the group with RLU > 10 (24.2%) showed statistical significance (p = 0.0002). Increasing hrHPV viral load significantly correlates with increasing prevalence of CIN2/CIN3 in ASC-US cases.
Original language | English |
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Pages (from-to) | 261-264 |
Number of pages | 4 |
Journal | European Journal of Gynaecological Oncology |
Volume | 33 |
Issue number | 3 |
Publication status | Published - 2012 |
Keywords
- ASC-US
- Cervical intraepithelial neoplasia
- CIN
- HC2
- HPV
- HPV-DNA
- Viral load
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology