TY - JOUR
T1 - Low incidence but poor prognosis of complicated coeliac disease
T2 - A retrospective multicentre study
AU - Biagi, Federico
AU - Gobbi, Paolo
AU - Marchese, Alessandra
AU - Borsotti, Edoardo
AU - Zingone, Fabiana
AU - Ciacci, Carolina
AU - Volta, Umberto
AU - Caio, Giacomo
AU - Carroccio, Antonio
AU - Ambrosiano, Giuseppe
AU - Mansueto, Pasquale
AU - Corazza, Gino R.
PY - 2014/3
Y1 - 2014/3
N2 - Background: Coeliac disease is a chronic enteropathy characterized by an increased mortality caused by its complications, mainly refractory coeliac disease, small bowel carcinoma and abdominal lymphoma. Aim of the study was to study the epidemiology of complications in patients with coeliac disease. Methods: Retrospective multicenter case-control study based on collection of clinical and laboratory data. The incidence of complicated coeliac disease was studied among coeliac patients directly diagnosed in four Italian centres. Patients referred to these centres after a diagnosis of coeliac disease and/or complicated coeliac disease in other hospitals were therefore excluded. Results: Between 1/1999 and 10/2011, 1840 adult coeliac patients were followed up for 7364.3 person-years. Fourteen developed complications. Since five patients died, at the end of the observation period (10/2011), the prevalence of complicated coeliac disease was 9/1835 (1/204, 0.49%, 95% CI 0.2-0.9%). The annual incidence of complicated coeliac disease in the study period was 14/7364 (0.2%, 95% CI 0.1-0.31%). Although complications tend to occur soon after the diagnosis of coeliac disease, Kaplan-Meier curve analysis showed that they can actually occur at any time after the diagnosis of coeliac disease. Conclusions: Complications of coeliac disease in our cohort were quite rare, though characterised by a very high mortality.
AB - Background: Coeliac disease is a chronic enteropathy characterized by an increased mortality caused by its complications, mainly refractory coeliac disease, small bowel carcinoma and abdominal lymphoma. Aim of the study was to study the epidemiology of complications in patients with coeliac disease. Methods: Retrospective multicenter case-control study based on collection of clinical and laboratory data. The incidence of complicated coeliac disease was studied among coeliac patients directly diagnosed in four Italian centres. Patients referred to these centres after a diagnosis of coeliac disease and/or complicated coeliac disease in other hospitals were therefore excluded. Results: Between 1/1999 and 10/2011, 1840 adult coeliac patients were followed up for 7364.3 person-years. Fourteen developed complications. Since five patients died, at the end of the observation period (10/2011), the prevalence of complicated coeliac disease was 9/1835 (1/204, 0.49%, 95% CI 0.2-0.9%). The annual incidence of complicated coeliac disease in the study period was 14/7364 (0.2%, 95% CI 0.1-0.31%). Although complications tend to occur soon after the diagnosis of coeliac disease, Kaplan-Meier curve analysis showed that they can actually occur at any time after the diagnosis of coeliac disease. Conclusions: Complications of coeliac disease in our cohort were quite rare, though characterised by a very high mortality.
KW - Celiac disease/epidemiology
KW - Gluten
KW - Incidence
KW - Prognosis
KW - Risk assessment
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U2 - 10.1016/j.dld.2013.10.010
DO - 10.1016/j.dld.2013.10.010
M3 - Article
C2 - 24268568
AN - SCOPUS:84893784324
VL - 46
SP - 227
EP - 230
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 3
ER -