Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

A. De Manzini; M. Andolina; E. Agosti; R. Giorgi; F. Locatelli; L. Bonetti; R. Miniero; A. Busca; F. Porta; A. Lanfranchi; F. Rossetti; P. Colleselli

Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

A. De Manzini, M. Andolina, E. Agosti, R. Giorgi, F. Locatelli, L. Bonetti, R. Miniero, A. Busca, F. Porta, A. Lanfranchi, F. Rossetti, P. Colleselli

Research output: Contribution to journal › Article › peer-review

Abstract

2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	11
Issue number	SUPPL. 1
Publication status	Published - 1993

ASJC Scopus subject areas

Hematology
Transplantation

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Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT. / De Manzini, A.; Andolina, M.; Agosti, E.; Giorgi, R.; Locatelli, F.; Bonetti, L.; Miniero, R.; Busca, A.; Porta, F.; Lanfranchi, A.; Rossetti, F.; Colleselli, P.

In: Bone Marrow Transplantation, Vol. 11, No. SUPPL. 1, 1993, p. 114-116.

Research output: Contribution to journal › Article › peer-review

De Manzini, A. ; Andolina, M. ; Agosti, E. ; Giorgi, R. ; Locatelli, F. ; Bonetti, L. ; Miniero, R. ; Busca, A. ; Porta, F. ; Lanfranchi, A. ; Rossetti, F. ; Colleselli, P. / Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT. In: Bone Marrow Transplantation. 1993 ; Vol. 11, No. SUPPL. 1. pp. 114-116.

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abstract = "2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.",

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AU - De Manzini, A.

AU - Andolina, M.

AU - Agosti, E.

AU - Giorgi, R.

AU - Locatelli, F.

AU - Bonetti, L.

AU - Miniero, R.

AU - Busca, A.

AU - Porta, F.

AU - Lanfranchi, A.

AU - Rossetti, F.

AU - Colleselli, P.

PY - 1993

Y1 - 1993

N2 - 2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

AB - 2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

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Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

Abstract

ASJC Scopus subject areas

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