Abstract
2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.
Original language | English |
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Pages (from-to) | 114-116 |
Number of pages | 3 |
Journal | Bone Marrow Transplantation |
Volume | 11 |
Issue number | SUPPL. 1 |
Publication status | Published - 1993 |
ASJC Scopus subject areas
- Hematology
- Transplantation