Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

A. De Manzini, M. Andolina, E. Agosti, R. Giorgi, F. Locatelli, L. Bonetti, R. Miniero, A. Busca, F. Porta, A. Lanfranchi, F. Rossetti, P. Colleselli

Research output: Contribution to journalArticle

Abstract

2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalBone Marrow Transplantation
Volume11
Issue numberSUPPL. 1
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    De Manzini, A., Andolina, M., Agosti, E., Giorgi, R., Locatelli, F., Bonetti, L., Miniero, R., Busca, A., Porta, F., Lanfranchi, A., Rossetti, F., & Colleselli, P. (1993). Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT. Bone Marrow Transplantation, 11(SUPPL. 1), 114-116.