Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

A. De Manzini; M. Andolina; E. Agosti; R. Giorgi; F. Locatelli; L. Bonetti; R. Miniero; A. Busca; F. Porta; A. Lanfranchi; F. Rossetti; P. Colleselli

Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

A. De Manzini, M. Andolina, E. Agosti, R. Giorgi, F. Locatelli, L. Bonetti, R. Miniero, A. Busca, F. Porta, A. Lanfranchi, F. Rossetti, P. Colleselli

Research output: Contribution to journal › Article › peer-review

Abstract

2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	11
Issue number	SUPPL. 1
Publication status	Published - 1993

ASJC Scopus subject areas

Hematology
Transplantation

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Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT. / De Manzini, A.; Andolina, M.; Agosti, E.; Giorgi, R.; Locatelli, F.; Bonetti, L.; Miniero, R.; Busca, A.; Porta, F.; Lanfranchi, A.; Rossetti, F.; Colleselli, P.

In: Bone Marrow Transplantation, Vol. 11, No. SUPPL. 1, 1993, p. 114-116.

Research output: Contribution to journal › Article › peer-review

De Manzini, A. ; Andolina, M. ; Agosti, E. ; Giorgi, R. ; Locatelli, F. ; Bonetti, L. ; Miniero, R. ; Busca, A. ; Porta, F. ; Lanfranchi, A. ; Rossetti, F. ; Colleselli, P. / Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT. In: Bone Marrow Transplantation. 1993 ; Vol. 11, No. SUPPL. 1. pp. 114-116.

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title = "Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT",

abstract = "2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.",

author = "{De Manzini}, A. and M. Andolina and E. Agosti and R. Giorgi and F. Locatelli and L. Bonetti and R. Miniero and A. Busca and F. Porta and A. Lanfranchi and F. Rossetti and P. Colleselli",

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language = "English",

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T1 - Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

AU - De Manzini, A.

AU - Andolina, M.

AU - Agosti, E.

AU - Giorgi, R.

AU - Locatelli, F.

AU - Bonetti, L.

AU - Miniero, R.

AU - Busca, A.

AU - Porta, F.

AU - Lanfranchi, A.

AU - Rossetti, F.

AU - Colleselli, P.

PY - 1993

Y1 - 1993

N2 - 2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

AB - 2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2° to 4° degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.

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AN - SCOPUS:0027419764

VL - 11

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JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - SUPPL. 1

ER -

Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT

Abstract

ASJC Scopus subject areas

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