Low insulin-like growth factor I and leukopenia in anorexia nervosa

Nicoletta Polli, Massimo Scacchi, Francesca Pecori Giraldi, Marica Sormani, Daniela Zappulli, Francesco Cavagnini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Considering that leukopenia and anemia are commonly observed in anorexia nervosa (AN) and that growth hormone (GH) and insulin-like growth factor-I (IGF-I) markedly influence the activation, growth and survival of hemopoietic cells, we sought for possible relationships between hematologic parameters and the GH-IGF-I axis in a group of patients with AN. Method: Twenty patients were studied. Leukocyte and erythrocyte counts, as well as baseline serum GH levels and IGF-I standard deviation score (SDS) values, were determined in each participant and correlations between parameters were searched. Results: Leukocyte and erythrocyte counts, as well as IGF-I SDS values, were significantly lower, conversely GH was significantly higher in AN patients than in normal weight participants. In patients, IGF-I SDS values were positively correlated with leukocyte count and BMI, whereas no correlation was found between IGF-I SDS and hemoglobin or erythrocytes. Conclusion: The demonstration of a positive correlation between leukocyte number and circulating IGF-I in AN suggests a likely pathogenetic role of IGF-I deficiency in this hematologic abnormality.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalInternational Journal of Eating Disorders
Volume41
Issue number4
DOIs
Publication statusPublished - May 2008

Fingerprint

leukopenia
anorexia nervosa
Anorexia Nervosa
Leukopenia
insulin-like growth factor I
Insulin-Like Growth Factor I
Leukocyte Count
Growth Hormone
leukocyte count
somatotropin
Erythrocyte Count
erythrocyte count
Anemia
Cell Survival
anemia
Hemoglobins
cell viability
Erythrocytes
hemoglobin
erythrocytes

Keywords

  • Anorexia nervosa
  • IGF-I
  • Leuropenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Food Science
  • Psychology(all)
  • Clinical Psychology

Cite this

Low insulin-like growth factor I and leukopenia in anorexia nervosa. / Polli, Nicoletta; Scacchi, Massimo; Giraldi, Francesca Pecori; Sormani, Marica; Zappulli, Daniela; Cavagnini, Francesco.

In: International Journal of Eating Disorders, Vol. 41, No. 4, 05.2008, p. 355-359.

Research output: Contribution to journalArticle

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AU - Zappulli, Daniela

AU - Cavagnini, Francesco

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AB - Objective: Considering that leukopenia and anemia are commonly observed in anorexia nervosa (AN) and that growth hormone (GH) and insulin-like growth factor-I (IGF-I) markedly influence the activation, growth and survival of hemopoietic cells, we sought for possible relationships between hematologic parameters and the GH-IGF-I axis in a group of patients with AN. Method: Twenty patients were studied. Leukocyte and erythrocyte counts, as well as baseline serum GH levels and IGF-I standard deviation score (SDS) values, were determined in each participant and correlations between parameters were searched. Results: Leukocyte and erythrocyte counts, as well as IGF-I SDS values, were significantly lower, conversely GH was significantly higher in AN patients than in normal weight participants. In patients, IGF-I SDS values were positively correlated with leukocyte count and BMI, whereas no correlation was found between IGF-I SDS and hemoglobin or erythrocytes. Conclusion: The demonstration of a positive correlation between leukocyte number and circulating IGF-I in AN suggests a likely pathogenetic role of IGF-I deficiency in this hematologic abnormality.

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