Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH-INS genes

Giuseppe Paolisso, Michelangela Barbieri, Maria Rosaria Rizzo, Carlo Carella, Mario Rotondi, Massimiliano Bonafè, Claudio Franceschi, Giuseppina Rose, Giovanna De Benedictis

Research output: Contribution to journalArticle

Abstract

Tyrosine Hydroxylase (TH) and Insulin (INS) genes lie extremely close in the 11p15.5 chromosomal region. An STR marker of the TH gene had revealed this locus associated with longevity. Thus, it seemed of interest to investigate the association between the TH-STR and INS gene variability (FokI-RFLP) with a phenotypic trait, such as the degree of insulin resistance (IR) and β-cell function in centenarians (C). We analyzed age-related trajectories of IR and β-cell function in a large sample (n = 466) of individuals whose age ranged from 28 to more than 100 years; furthermore, allele average effects on IR and β-cell function relevant to TH-STR and INS-FokI polymorphisms were estimated in C. Both IR and β-cell function increased with advancing age and declined in subjects older than 90 years (p for trend

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalExperimental Gerontology
Volume37
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Centenarians
  • Glucose metabolism
  • Human longevity
  • TH-INS genes

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Fingerprint Dive into the research topics of 'Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH-INS genes'. Together they form a unique fingerprint.

  • Cite this