Low level of p27(Kip1) protein expression in gastric adenocarcinoma is associated with disease progression and poor outcome

Donato Nitti, Claudio Belluco, Enzo Mammano, Alberto Marchet, Alessandro Ambrosi, Roberto Mencarelli, Paola Segato, Mario Lise

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: Low tumor expression of the p27Kip1 protein, which is involved in cell cycle control and apoptosis, is considered a negative prognostic factor in different types of cancer. The aim of this study was to evaluate the clinical and pathological significance of low p27Kip1 protein expression in patients who had undergone resection for gastric adenocarcinoma. Methods: p27Kip1 protein was studied by immunohistochemistry in formalin-fixed tumor sections from 95 patients who underwent resection for gastric adenocarcinoma between 1991 and 1996. Based on the median value of protein expression, p27Kip1 protein expression was classified as low or high. Results: Low p27Kip1 protein expression was significantly associated with tumor dedifferentiation, increased penetration through the gastric wall, lymph node metastasis, and advanced tumor stage. In the group of 84 patients who underwent curative surgery, 5-year survival was 74% in cases with high p27Kip1 protein expression and 38% in those with low p27Kip1 protein expression (P <0.001). At multivariate analysis, low p27Kip1 protein expression was an independent negative prognostic factor for survival (RR = 3.671; P = 0.004). Conclusions: In gastric adenocarcinoma, low p27Kip1 protein expression is associated with poorly differentiated and advanced tumors and is a negative prognostic factor of potential clinical value.

Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalJournal of Surgical Oncology
Volume81
Issue number4
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Gastric cancer
  • Immunohistochemistry
  • Multivariate analysis
  • P27 protein
  • Prognosis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint

Dive into the research topics of 'Low level of p27(Kip1) protein expression in gastric adenocarcinoma is associated with disease progression and poor outcome'. Together they form a unique fingerprint.

Cite this