TY - JOUR
T1 - Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men
AU - Gigante, Bruna
AU - Leander, Karin
AU - Vikstro¨m, Max
AU - Baldassarre, Damiano
AU - Veglia, Fabrizio
AU - Strawbridge, Rona J.
AU - McLeod, Olga
AU - Gertow, Karl
AU - Sennblad, Bengt
AU - Shah, Sonia
AU - Zabaneh, Delilah
AU - Humphries, Steve E.
AU - Kauhanen, Jussi
AU - Rauramaa, Rainer
AU - Smit, Andries J.
AU - Mannarino, Elmo
AU - Giral, Philippe
AU - Tremoli, Elena
AU - Hamsten, Anders
AU - Frostega˚rd, Johan
AU - de Faire, Ulf
PY - 2014/8/5
Y1 - 2014/8/5
N2 - Objective: Low levels of IgM anti-phosphorylcholine (anti-PC) increase the risk of cardiovascular events (CVE). Here we investigate the association of low anti-PC with the progression of carotid intima media thickness (C-IMT) and incidence of CVE in a large cohort of individuals at high risk of CVE, the IMPROVE, a prospective multicenter European study. Methods: 3711 subjects (54-79 years) with at least three established cardiovascular risk factors were enrolled. Baseline serum levels of IgM anti-PC were measured by ELISA. Carotid ultrasound investigations were performed at baseline and after 15 and 30 months of follow-up. The risk of C-IMT progression and ischemic CVE associated with low anti-PC levels was tested by logistic regression and Cox regression analysis, respectively. Risk estimates were adjusted by center and conventional cardiovascular risk factors. Results: 3670 study participants were included in the present analysis and 213 CVE were recorded during a 3 year follow up. Anti-PC levels (U/ml) were classified into quartiles [. Q1≤ 40, Q2 >40-≤64, Q3 >64-≤102, Q4 >102]. In men, low levels of anti-PC (Q1) were associated with the highest (>90th) percentile of the fastest C-IMT progression, i.e. the segment showing the fastest progression over 30 months in the whole carotid tree, with an OR of 1.41 (95%CI, 1.02-1.9) and with an increased risk of CVE with a multivariable adjusted HR of 1.85 (95%CI, 1.1-3.1). No significant associations were found in women. Conclusions: Low anti-PC levels increase the risk of CVE in men. This effect may be partly mediated by a fast C-IMT progression.
AB - Objective: Low levels of IgM anti-phosphorylcholine (anti-PC) increase the risk of cardiovascular events (CVE). Here we investigate the association of low anti-PC with the progression of carotid intima media thickness (C-IMT) and incidence of CVE in a large cohort of individuals at high risk of CVE, the IMPROVE, a prospective multicenter European study. Methods: 3711 subjects (54-79 years) with at least three established cardiovascular risk factors were enrolled. Baseline serum levels of IgM anti-PC were measured by ELISA. Carotid ultrasound investigations were performed at baseline and after 15 and 30 months of follow-up. The risk of C-IMT progression and ischemic CVE associated with low anti-PC levels was tested by logistic regression and Cox regression analysis, respectively. Risk estimates were adjusted by center and conventional cardiovascular risk factors. Results: 3670 study participants were included in the present analysis and 213 CVE were recorded during a 3 year follow up. Anti-PC levels (U/ml) were classified into quartiles [. Q1≤ 40, Q2 >40-≤64, Q3 >64-≤102, Q4 >102]. In men, low levels of anti-PC (Q1) were associated with the highest (>90th) percentile of the fastest C-IMT progression, i.e. the segment showing the fastest progression over 30 months in the whole carotid tree, with an OR of 1.41 (95%CI, 1.02-1.9) and with an increased risk of CVE with a multivariable adjusted HR of 1.85 (95%CI, 1.1-3.1). No significant associations were found in women. Conclusions: Low anti-PC levels increase the risk of CVE in men. This effect may be partly mediated by a fast C-IMT progression.
KW - Anti-PC
KW - Biomarker
KW - Cardiovascular disease
KW - Cardiovascular events
KW - Carotid intima media thickness
KW - Carotid intima media thickness progression
KW - Risk factors
KW - Subclinical atherosclerosis
UR - http://www.scopus.com/inward/record.url?scp=84907086030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907086030&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2014.07.030
DO - 10.1016/j.atherosclerosis.2014.07.030
M3 - Article
C2 - 25150937
AN - SCOPUS:84907086030
VL - 236
SP - 394
EP - 399
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -