Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children

Carlo Agostoni, Gian Vincenzo Zuccotti, Enrica Riva, Silvia Decarlis, Luca Bernardo, Maria G. Bruzzese, Marcello Giovannini

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To assess the plasma fatty acid status of a group of well- nourished children with the human immunodeficiency virus type-1 (HIV-1) and how this relates to the blood total CD4+ lymphocyte count. Subjects: Fourteen HIV-1 seropositive children at various stages of disease and with adequate growth indices woe assessed and compared to a control group of 30 healthy children. Results: The concentrations (mg/dL) of plasma total fatty acids were not different between the two groups. HIV-1 seropositive children presented lower levels of 18-C essential polyunsaturated fatty acids (PUFA: linoleic acid, LA, and alpha-linolenic acid) and higher levels of their 20-C long-chain derivatives (di-homo-γ-linolenic acid, arachidonic acid, AA, and eicosapentaenoic acid) and docosahexaenoic acid in their plasma total lipids. The lowest plasma LA levels were observed in the subgroup of patients with more advanced stages of disease. In bivariate analyses the plasma LA levels related positively (Spearman r=0.50, p=0.06), while the LA/AA ratio related negatively (Spearman r=-0.51, p=0.06), to the total CD4+ count. Conclusions: Childhood HIV-1 infection is associated with changes in plasma fatty acid profile suggestive of an increased PUFA turnover. Decreased levels of LA (together with higher plasma AA levels) appear to be associated with more advanced clinical and biochemical stages of disease.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of the American College of Nutrition
Volume17
Issue number1
Publication statusPublished - 1998

Fingerprint

Linoleic Acid
Human immunodeficiency virus 1
HIV-1
linoleic acid
Lipids
lipids
alpha-Linolenic Acid
Fatty Acids
fatty acids
CD4 Lymphocyte Count
lymphocyte count
alpha-linolenic acid
Homo
essential fatty acids
eicosapentaenoic acid
linolenic acid
docosahexaenoic acid
arachidonic acid
childhood
polyunsaturated fatty acids

Keywords

  • HIV-1 childhood infection
  • Linoleic acid
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Agostoni, C., Zuccotti, G. V., Riva, E., Decarlis, S., Bernardo, L., Bruzzese, M. G., & Giovannini, M. (1998). Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children. Journal of the American College of Nutrition, 17(1), 25-29.

Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children. / Agostoni, Carlo; Zuccotti, Gian Vincenzo; Riva, Enrica; Decarlis, Silvia; Bernardo, Luca; Bruzzese, Maria G.; Giovannini, Marcello.

In: Journal of the American College of Nutrition, Vol. 17, No. 1, 1998, p. 25-29.

Research output: Contribution to journalArticle

Agostoni, C, Zuccotti, GV, Riva, E, Decarlis, S, Bernardo, L, Bruzzese, MG & Giovannini, M 1998, 'Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children', Journal of the American College of Nutrition, vol. 17, no. 1, pp. 25-29.
Agostoni, Carlo ; Zuccotti, Gian Vincenzo ; Riva, Enrica ; Decarlis, Silvia ; Bernardo, Luca ; Bruzzese, Maria G. ; Giovannini, Marcello. / Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children. In: Journal of the American College of Nutrition. 1998 ; Vol. 17, No. 1. pp. 25-29.
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