Low-molecular -weight heparin in pregnancies after ART -A retrospective study-

E. Grandone, M. Villani, F. Dentali, G. L. Tiscia, D. Colaizzo, F. Cappucci, L. Fischetti, W. Ageno, M. Margaglione

Research output: Contribution to journalArticlepeer-review


Introduction The utility of an antithrombotic prophylaxis in Assisted Reproductive Technologies (ART) is highly debated. It has been hypothesised that specific effects of heparin on the coagulation system during implantation can improve the number of clinical pregnancies and live births. Materials and Methods We studied a cohort of 327 women undergone at least 1 ART cycle before thrombophilia testing. Overall, a number of 751 cycles was analysed. Low-Molecular-Weight Heparin (LMWH) and/or low-dose aspirin (ASA) were prescribed in 132 (17.6%) cycles. Furthermore, all the women underwent thrombophilia screening. Results The univariate analysis showed that LMWH with/without ASA was significantly associated with both the outcomes clinical pregnancy and live birth, while the use of ASA was not associated with live birth. The logistic regression showed that the use of LMWH was significantly associated with both the outcomes, clinical pregnancy (OR: 6.0, 95%CI: 2.8-15.6) and live birth (OR: 10.7, 95%CI: 3.2-36.1). The type of ART procedure significantly influenced the likelihood of achieving clinical pregnancy. Conclusions Present findings suggest that LMWH alone or combined with ASA could have a role in fostering the implantation of embryos and improving the number of live births after ART.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalThrombosis Research
Issue number2
Publication statusPublished - 2014


  • Aspirin
  • Assisted Reproductive Technologies
  • Low-molecular- weight heparins

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)


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