Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women

Giorgio Mello, Elena Parretti, Cinzia Fatini, Chiara Riviello, Francesca Gensini, Mauro Marchionni, Gian Franco Scarselli, Gian Franco Gensini, Rosanna Abbate

Research output: Contribution to journalArticle

Abstract

Data from literature report that angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism affects the recurrence of preeclampsia and that low-molecular-weight heparin (LMWH) prevents adverse outcomes in thrombophilic women. We investigated the effect of LMWH on the pregnancy outcome, on maternal blood pressure values, and on uteroplacental flow in ACE DD nonthrombophilic women with history of preeclampsia. Eighty nonthrombophilic ACE DD women were randomized in 2 groups: 41 treated with dalteparin 5000 IU/day and 39 untreated (control group). Women underwent 24-hour automated blood pressure monitoring in the preconceptional period and every 2 weeks from weeks 8 to 36 and transabdominal color flow/pulsed Doppler examination at weeks 16, 20, and 24. LMWH reduced the risk of clinical negative outcomes (74.1% reduction of preeclampsia and 77.5% reduction of fetal growth restriction) and the severity (88.3% reduction of early onset of preeclampsia and 86.4% reduction of early onset of fetal growth restriction). In treated women, the relative risk for preeclampsia was 0.26 (P=0.02), and the relative risk for fetal growth restriction was 0.14 (P

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalHypertension
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2005

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Keywords

  • Angiotensin-converting enzyme
  • Heparin
  • Preeclampsia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Mello, G., Parretti, E., Fatini, C., Riviello, C., Gensini, F., Marchionni, M., Scarselli, G. F., Gensini, G. F., & Abbate, R. (2005). Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women. Hypertension, 45(1), 86-91. https://doi.org/10.1161/01.HYP.0000149950.05182.a3