Abstract
Background: The aim of the current study was to perform two separate meta-analyses of available studies comparing low-molecular-weight heparins (LMWHs) vs. unfractionated heparin (UFH) in ST-elevation myocardial infarction (STEMI) patients treated (i) with primary percutaneous coronary intervention (pPCI) or (ii) with PCI after thrombolysis. Methods: All-cause mortality was the pre-specified primary endpoint and major bleeding complications were recorded as the secondary endpoints. Relative risk (RR) with a 95% confidence interval (CI) and absolute risk reduction (ARR) were chosen as the effect measure. Results: Ten studies comprising 16286 patients were included. The median follow-up was 2months for the primary endpoint. Among LMWHs, enoxaparin was the compound most frequently used. In the pPCI group, LMWHs were associated with a reduction in mortality [RR (95% CI)=0.51 (0.41-0.64), P
| Original language | English |
|---|---|
| Pages (from-to) | 1902-1915 |
| Number of pages | 14 |
| Journal | Journal of Thrombosis and Haemostasis |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- Low-molecular-weight heparin
- Percutaneous coronary intervention
- ST-elevation myocardial infarction
- Unfractionated heparin
ASJC Scopus subject areas
- Hematology
Cite this
Low-molecular-weight heparins vs. unfractionated heparin in the setting of percutaneous coronary intervention for ST-elevation myocardial infarction : A meta-analysis. / Navarese, E. P.; De Luca, G.; Castriota, F.; Kozinski, M.; Gurbel, P. A.; Gibson, C. M.; Andreotti, F.; Buffon, A.; Siller-Matula, J. M.; Sukiennik, A.; De Servi, S.; Kubica, J.
In: Journal of Thrombosis and Haemostasis, Vol. 9, No. 10, 10.2011, p. 1902-1915.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low-molecular-weight heparins vs. unfractionated heparin in the setting of percutaneous coronary intervention for ST-elevation myocardial infarction
T2 - A meta-analysis
AU - Navarese, E. P.
AU - De Luca, G.
AU - Castriota, F.
AU - Kozinski, M.
AU - Gurbel, P. A.
AU - Gibson, C. M.
AU - Andreotti, F.
AU - Buffon, A.
AU - Siller-Matula, J. M.
AU - Sukiennik, A.
AU - De Servi, S.
AU - Kubica, J.
PY - 2011/10
Y1 - 2011/10
N2 - Background: The aim of the current study was to perform two separate meta-analyses of available studies comparing low-molecular-weight heparins (LMWHs) vs. unfractionated heparin (UFH) in ST-elevation myocardial infarction (STEMI) patients treated (i) with primary percutaneous coronary intervention (pPCI) or (ii) with PCI after thrombolysis. Methods: All-cause mortality was the pre-specified primary endpoint and major bleeding complications were recorded as the secondary endpoints. Relative risk (RR) with a 95% confidence interval (CI) and absolute risk reduction (ARR) were chosen as the effect measure. Results: Ten studies comprising 16286 patients were included. The median follow-up was 2months for the primary endpoint. Among LMWHs, enoxaparin was the compound most frequently used. In the pPCI group, LMWHs were associated with a reduction in mortality [RR (95% CI)=0.51 (0.41-0.64), P
AB - Background: The aim of the current study was to perform two separate meta-analyses of available studies comparing low-molecular-weight heparins (LMWHs) vs. unfractionated heparin (UFH) in ST-elevation myocardial infarction (STEMI) patients treated (i) with primary percutaneous coronary intervention (pPCI) or (ii) with PCI after thrombolysis. Methods: All-cause mortality was the pre-specified primary endpoint and major bleeding complications were recorded as the secondary endpoints. Relative risk (RR) with a 95% confidence interval (CI) and absolute risk reduction (ARR) were chosen as the effect measure. Results: Ten studies comprising 16286 patients were included. The median follow-up was 2months for the primary endpoint. Among LMWHs, enoxaparin was the compound most frequently used. In the pPCI group, LMWHs were associated with a reduction in mortality [RR (95% CI)=0.51 (0.41-0.64), P
KW - Low-molecular-weight heparin
KW - Percutaneous coronary intervention
KW - ST-elevation myocardial infarction
KW - Unfractionated heparin
UR - http://www.scopus.com/inward/record.url?scp=80053424432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053424432&partnerID=8YFLogxK
U2 - 10.1111/j.1538-7836.2011.04445.x
DO - 10.1111/j.1538-7836.2011.04445.x
M3 - Article
C2 - 21777368
AN - SCOPUS:80053424432
VL - 9
SP - 1902
EP - 1915
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
SN - 1538-7933
IS - 10
ER -