Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis

M. Cattaneo, R. Lombardi, A. Lecchi, P. Bucciarelli, P. M. Mannucci

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Abstract

Background - Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT). We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT. Methods and Results - We compared 397 cases with previous DVT with 585 matched healthy controls. The plasma levels of folate, vitamin B12, vitamin B6, and fasting and PML tHcy were measured. The ORs for DVT associated with high (>95th percentile) fasting levels and PML increases of tHcy were 2.1 (95% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for established risk factors for DVT. Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels. The crude OR for folate levels in the lowest quartile compared with the highest was 1.5 (95% CI, 1.1 to 2.1), and that for B6 levels in the lowest and second quartiles compared with the highest was 1.5 (95% CI, 1.0 to 2.1). However, after adjustment for established risk factors and fasting and PML tHcy, the ORs for B6 levels in the lowest and second quartiles only remained statistically significant (lowest quartile: OR, 1.8; 95% CI, 1.2 to 2.8; second quartile, OR, 1.9; 95% CI, 1.3 to 2.9). Conclusions - High fasting and PML tHcy and low vitamin B6 plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT. The association of low vitamin B6 levels with the risk for DVT is independent of fasting and PML tHcy levels.

Original languageEnglish
Pages (from-to)2442-2446
Number of pages5
JournalCirculation
Volume104
Issue number20
Publication statusPublished - Nov 13 2001

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Vitamin B 6
Venous Thrombosis
Homocysteine
Fasting
Folic Acid
Vitamin B Complex
Vitamin B 12
Vitamins
Methionine

Keywords

  • Homocysteine
  • Risk factors
  • Thrombosis
  • Veins
  • Vitamin B

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis. / Cattaneo, M.; Lombardi, R.; Lecchi, A.; Bucciarelli, P.; Mannucci, P. M.

In: Circulation, Vol. 104, No. 20, 13.11.2001, p. 2442-2446.

Research output: Contribution to journalArticle

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title = "Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis",
abstract = "Background - Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT). We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT. Methods and Results - We compared 397 cases with previous DVT with 585 matched healthy controls. The plasma levels of folate, vitamin B12, vitamin B6, and fasting and PML tHcy were measured. The ORs for DVT associated with high (>95th percentile) fasting levels and PML increases of tHcy were 2.1 (95{\%} CI, 1.2 to 3.4) and 2.4 (95{\%} CI, 1.5 to 3.9) after adjustment for established risk factors for DVT. Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels. The crude OR for folate levels in the lowest quartile compared with the highest was 1.5 (95{\%} CI, 1.1 to 2.1), and that for B6 levels in the lowest and second quartiles compared with the highest was 1.5 (95{\%} CI, 1.0 to 2.1). However, after adjustment for established risk factors and fasting and PML tHcy, the ORs for B6 levels in the lowest and second quartiles only remained statistically significant (lowest quartile: OR, 1.8; 95{\%} CI, 1.2 to 2.8; second quartile, OR, 1.9; 95{\%} CI, 1.3 to 2.9). Conclusions - High fasting and PML tHcy and low vitamin B6 plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT. The association of low vitamin B6 levels with the risk for DVT is independent of fasting and PML tHcy levels.",
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T1 - Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis

AU - Cattaneo, M.

AU - Lombardi, R.

AU - Lecchi, A.

AU - Bucciarelli, P.

AU - Mannucci, P. M.

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N2 - Background - Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT). We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT. Methods and Results - We compared 397 cases with previous DVT with 585 matched healthy controls. The plasma levels of folate, vitamin B12, vitamin B6, and fasting and PML tHcy were measured. The ORs for DVT associated with high (>95th percentile) fasting levels and PML increases of tHcy were 2.1 (95% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for established risk factors for DVT. Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels. The crude OR for folate levels in the lowest quartile compared with the highest was 1.5 (95% CI, 1.1 to 2.1), and that for B6 levels in the lowest and second quartiles compared with the highest was 1.5 (95% CI, 1.0 to 2.1). However, after adjustment for established risk factors and fasting and PML tHcy, the ORs for B6 levels in the lowest and second quartiles only remained statistically significant (lowest quartile: OR, 1.8; 95% CI, 1.2 to 2.8; second quartile, OR, 1.9; 95% CI, 1.3 to 2.9). Conclusions - High fasting and PML tHcy and low vitamin B6 plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT. The association of low vitamin B6 levels with the risk for DVT is independent of fasting and PML tHcy levels.

AB - Background - Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT). We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT. Methods and Results - We compared 397 cases with previous DVT with 585 matched healthy controls. The plasma levels of folate, vitamin B12, vitamin B6, and fasting and PML tHcy were measured. The ORs for DVT associated with high (>95th percentile) fasting levels and PML increases of tHcy were 2.1 (95% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for established risk factors for DVT. Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels. The crude OR for folate levels in the lowest quartile compared with the highest was 1.5 (95% CI, 1.1 to 2.1), and that for B6 levels in the lowest and second quartiles compared with the highest was 1.5 (95% CI, 1.0 to 2.1). However, after adjustment for established risk factors and fasting and PML tHcy, the ORs for B6 levels in the lowest and second quartiles only remained statistically significant (lowest quartile: OR, 1.8; 95% CI, 1.2 to 2.8; second quartile, OR, 1.9; 95% CI, 1.3 to 2.9). Conclusions - High fasting and PML tHcy and low vitamin B6 plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT. The association of low vitamin B6 levels with the risk for DVT is independent of fasting and PML tHcy levels.

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