Low plasma stem cell factor levels correlate with in vitro leukemic growth in myelodysplastic syndromes

Agostino Cortelezzi, Chiara Cattaneo, Silvia Cristiani, Barbara Sarina, Mauro Pomati, Ilaria Silvestris, Adalberto Ibatici, Anna Teresa Maiolo

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Abstract

We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/cluster ratio. No correlation was found between BM plasma SCF levels, the pattern of growth and CD34 + c-kit + expression. These data seem to exclude any direct effect of SCF on leukemogenesis, but suggest that low plasma SCF levels may be at least partially responsible for leukemic growth in MDS.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalLeukemia Research
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 1999

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Keywords

  • c-kit
  • Clonogenic assay
  • Myelodysplastic syndromes
  • Stem cell factor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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