Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas

Marina N. Nikiforova, Raffaele Ciampi, Giuliana Salvatore, Massimo Santoro, Manoj Gandhi, Jeffrey A. Knauf, Gerry A. Thomas, Stephen Jeremiah, Tatyana I. Bogdanova, Mykola D. Tronko, James A. Fagin, Yuri E. Nikiforov

Research output: Contribution to journalArticle

Abstract

Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCancer Letters
Volume209
Issue number1
DOIs
Publication statusPublished - Jun 2004

Keywords

  • BRAF mutation
  • Radiation exposure
  • RET/PTC Rearrangement
  • Thyroid cancer

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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  • Cite this

    Nikiforova, M. N., Ciampi, R., Salvatore, G., Santoro, M., Gandhi, M., Knauf, J. A., Thomas, G. A., Jeremiah, S., Bogdanova, T. I., Tronko, M. D., Fagin, J. A., & Nikiforov, Y. E. (2004). Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer Letters, 209(1), 1-6. https://doi.org/10.1016/j.canlet.2003.12.004