Abstract
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
Original language | English |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Cancer Letters |
Volume | 209 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jun 2004 |
Keywords
- BRAF mutation
- Radiation exposure
- RET/PTC Rearrangement
- Thyroid cancer
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology