Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas

Marina N. Nikiforova; Raffaele Ciampi; Giuliana Salvatore; Massimo Santoro; Manoj Gandhi; Jeffrey A. Knauf; Gerry A. Thomas; Stephen Jeremiah; Tatyana I. Bogdanova; Mykola D. Tronko; James A. Fagin; Yuri E. Nikiforov

doi:10.1016/j.canlet.2003.12.004

Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas

Marina N. Nikiforova, Raffaele Ciampi, Giuliana Salvatore, Massimo Santoro, Manoj Gandhi, Jeffrey A. Knauf, Gerry A. Thomas, Stephen Jeremiah, Tatyana I. Bogdanova, Mykola D. Tronko, James A. Fagin, Yuri E. Nikiforov

IRCCS SDN

Research output: Contribution to journal › Article

Abstract

Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Cancer Letters
Volume	209
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2003.12.004
Publication status	Published - Jun 2004

Keywords

BRAF mutation
Radiation exposure
RET/PTC Rearrangement
Thyroid cancer

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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Nikiforova, M. N., Ciampi, R., Salvatore, G., Santoro, M., Gandhi, M., Knauf, J. A., Thomas, G. A., Jeremiah, S., Bogdanova, T. I., Tronko, M. D., Fagin, J. A., & Nikiforov, Y. E. (2004). Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer Letters, 209(1), 1-6. https://doi.org/10.1016/j.canlet.2003.12.004

Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. / Nikiforova, Marina N.; Ciampi, Raffaele; Salvatore, Giuliana; Santoro, Massimo; Gandhi, Manoj; Knauf, Jeffrey A.; Thomas, Gerry A.; Jeremiah, Stephen; Bogdanova, Tatyana I.; Tronko, Mykola D.; Fagin, James A.; Nikiforov, Yuri E.

In: Cancer Letters, Vol. 209, No. 1, 06.2004, p. 1-6.

Research output: Contribution to journal › Article

Nikiforova, Marina N. ; Ciampi, Raffaele ; Salvatore, Giuliana ; Santoro, Massimo ; Gandhi, Manoj ; Knauf, Jeffrey A. ; Thomas, Gerry A. ; Jeremiah, Stephen ; Bogdanova, Tatyana I. ; Tronko, Mykola D. ; Fagin, James A. ; Nikiforov, Yuri E. / Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. In: Cancer Letters. 2004 ; Vol. 209, No. 1. pp. 1-6.

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abstract = "Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.",

keywords = "BRAF mutation, Radiation exposure, RET/PTC Rearrangement, Thyroid cancer",

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AU - Ciampi, Raffaele

AU - Salvatore, Giuliana

AU - Santoro, Massimo

AU - Gandhi, Manoj

AU - Knauf, Jeffrey A.

AU - Thomas, Gerry A.

AU - Jeremiah, Stephen

AU - Bogdanova, Tatyana I.

AU - Tronko, Mykola D.

AU - Fagin, James A.

AU - Nikiforov, Yuri E.

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AB - Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.

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