Abstract
Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.
| Original language | English |
|---|---|
| Journal | International Journal of Infectious Diseases |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2013 |
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Keywords
- Bolivia
- Community settings
- Latin America
- MRSA
- Nasal carriage
- Peru
- Staphylococcus aureus
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru. / Bartoloni, Alessandro; Pallecchi, Lucia; Fernandez, Connie; Mantella, Antonia; Riccobono, Eleonora; Magnelli, Donata; Mannini, Dario; Strohmeyer, Marianne; Bartalesi, Filippo; Segundo, Higinio; Monasterio, Joaquin; Rodriguez, Hugo; Cabezas, César; Gotuzzo, Eduardo; Rossolini, Gian Maria.
In: International Journal of Infectious Diseases, Vol. 17, No. 5, 05.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru
AU - Bartoloni, Alessandro
AU - Pallecchi, Lucia
AU - Fernandez, Connie
AU - Mantella, Antonia
AU - Riccobono, Eleonora
AU - Magnelli, Donata
AU - Mannini, Dario
AU - Strohmeyer, Marianne
AU - Bartalesi, Filippo
AU - Segundo, Higinio
AU - Monasterio, Joaquin
AU - Rodriguez, Hugo
AU - Cabezas, César
AU - Gotuzzo, Eduardo
AU - Rossolini, Gian Maria
PY - 2013/5
Y1 - 2013/5
N2 - Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.
AB - Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.
KW - Bolivia
KW - Community settings
KW - Latin America
KW - MRSA
KW - Nasal carriage
KW - Peru
KW - Staphylococcus aureus
UR - http://www.scopus.com/inward/record.url?scp=84876095758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876095758&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2012.11.017
DO - 10.1016/j.ijid.2012.11.017
M3 - Article
C2 - 23266336
AN - SCOPUS:84876095758
VL - 17
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
IS - 5
ER -