Abstract
We studied the effect of dietary protein restriction on glomerular function and proteinuria in nine patients with membranous nephropathy. Patients were randomly assigned to a 3-month period of a normal protein diet (NPD, 1.3 mg/kg/d) or of a low-protein diet (LPD, 0.6 mg/kg/d), in a cross-over design. Dietary protein restriction did not affect glomerular filtration rate (47.8 ± 10.7 and 49.0 ± 13.5 mL/min/1.73 m2, LPD and NPD, respectively) and renal plasma flow (456 ± 119 and 499 ± 161 mL/min/1.73 m2, LPD and NPD, respectively), nor did it significantly improve glomerular permselective function, as shown by urinary protein excretion (3.1 ± 2.2 and 3.5 ± 2.8 g/d, LPD and NPD, respectively) and fractional clearance of albumin, IgG, and neutral dextran molecules of graded molecular size (radii ranging from 2.8 to 6.0 nm). These results indicate that reduction of protein intake to 0.6 g/kg/d does not improve glomerular size selectivity in membranous nephropathy. Thus, in current clinical practice, a protein-restricted diet does not appear to be effective in reducing proteinuria in this category of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 317-322 |
| Number of pages | 6 |
| Journal | American Journal of Kidney Diseases |
| Volume | 17 |
| Issue number | 3 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Nephrology
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Low-protein diet and glomerular size-selective function in membranous glomerulopathy. / Remuzzi, A.; Perticucci, E.; Battaglia, C.; D'Amico, G.; Gentile, M. G.; Remuzzi, G.
In: American Journal of Kidney Diseases, Vol. 17, No. 3, 1991, p. 317-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low-protein diet and glomerular size-selective function in membranous glomerulopathy
AU - Remuzzi, A.
AU - Perticucci, E.
AU - Battaglia, C.
AU - D'Amico, G.
AU - Gentile, M. G.
AU - Remuzzi, G.
PY - 1991
Y1 - 1991
N2 - We studied the effect of dietary protein restriction on glomerular function and proteinuria in nine patients with membranous nephropathy. Patients were randomly assigned to a 3-month period of a normal protein diet (NPD, 1.3 mg/kg/d) or of a low-protein diet (LPD, 0.6 mg/kg/d), in a cross-over design. Dietary protein restriction did not affect glomerular filtration rate (47.8 ± 10.7 and 49.0 ± 13.5 mL/min/1.73 m2, LPD and NPD, respectively) and renal plasma flow (456 ± 119 and 499 ± 161 mL/min/1.73 m2, LPD and NPD, respectively), nor did it significantly improve glomerular permselective function, as shown by urinary protein excretion (3.1 ± 2.2 and 3.5 ± 2.8 g/d, LPD and NPD, respectively) and fractional clearance of albumin, IgG, and neutral dextran molecules of graded molecular size (radii ranging from 2.8 to 6.0 nm). These results indicate that reduction of protein intake to 0.6 g/kg/d does not improve glomerular size selectivity in membranous nephropathy. Thus, in current clinical practice, a protein-restricted diet does not appear to be effective in reducing proteinuria in this category of patients.
AB - We studied the effect of dietary protein restriction on glomerular function and proteinuria in nine patients with membranous nephropathy. Patients were randomly assigned to a 3-month period of a normal protein diet (NPD, 1.3 mg/kg/d) or of a low-protein diet (LPD, 0.6 mg/kg/d), in a cross-over design. Dietary protein restriction did not affect glomerular filtration rate (47.8 ± 10.7 and 49.0 ± 13.5 mL/min/1.73 m2, LPD and NPD, respectively) and renal plasma flow (456 ± 119 and 499 ± 161 mL/min/1.73 m2, LPD and NPD, respectively), nor did it significantly improve glomerular permselective function, as shown by urinary protein excretion (3.1 ± 2.2 and 3.5 ± 2.8 g/d, LPD and NPD, respectively) and fractional clearance of albumin, IgG, and neutral dextran molecules of graded molecular size (radii ranging from 2.8 to 6.0 nm). These results indicate that reduction of protein intake to 0.6 g/kg/d does not improve glomerular size selectivity in membranous nephropathy. Thus, in current clinical practice, a protein-restricted diet does not appear to be effective in reducing proteinuria in this category of patients.
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M3 - Article
C2 - 1996576
AN - SCOPUS:0025821813
VL - 17
SP - 317
EP - 322
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 3
ER -