Low-protein diet and glomerular size-selective function in membranous glomerulopathy

A. Remuzzi, E. Perticucci, C. Battaglia, G. D'Amico, M. G. Gentile, G. Remuzzi

Research output: Contribution to journalArticle

Abstract

We studied the effect of dietary protein restriction on glomerular function and proteinuria in nine patients with membranous nephropathy. Patients were randomly assigned to a 3-month period of a normal protein diet (NPD, 1.3 mg/kg/d) or of a low-protein diet (LPD, 0.6 mg/kg/d), in a cross-over design. Dietary protein restriction did not affect glomerular filtration rate (47.8 ± 10.7 and 49.0 ± 13.5 mL/min/1.73 m2, LPD and NPD, respectively) and renal plasma flow (456 ± 119 and 499 ± 161 mL/min/1.73 m2, LPD and NPD, respectively), nor did it significantly improve glomerular permselective function, as shown by urinary protein excretion (3.1 ± 2.2 and 3.5 ± 2.8 g/d, LPD and NPD, respectively) and fractional clearance of albumin, IgG, and neutral dextran molecules of graded molecular size (radii ranging from 2.8 to 6.0 nm). These results indicate that reduction of protein intake to 0.6 g/kg/d does not improve glomerular size selectivity in membranous nephropathy. Thus, in current clinical practice, a protein-restricted diet does not appear to be effective in reducing proteinuria in this category of patients.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume17
Issue number3
Publication statusPublished - 1991

    Fingerprint

ASJC Scopus subject areas

  • Nephrology

Cite this

Remuzzi, A., Perticucci, E., Battaglia, C., D'Amico, G., Gentile, M. G., & Remuzzi, G. (1991). Low-protein diet and glomerular size-selective function in membranous glomerulopathy. American Journal of Kidney Diseases, 17(3), 317-322.