Low-protein diet and xanthine-metabolising enzyme in Adriamycin nephrosis

F. Ginevri, G. M. Ghiggeri, R. Oleggini, G. Barbano, R. Bertelli, G. Candiano, F. Perfumo, R. Gusmano

Research output: Contribution to journalArticle

Abstract

Proteinuria and renal xanthine metabolising enzymes, xanthine oxidase and xanthine dehydrogenase, were evaluated in Adriamycin-treated rats fed standard (21% casein) and low-protein (6% casein) diets. In rats fed a standard diet Adriamycin was associated with increased activities in the kidney of xanthine oxidase and xanthine dehydrogenase and induced massive proteinuria. The pharmacological block of both enzymes by allopurinol and tungsten reduced proteinuria to one-third of the original levels. Rats fed a low-protein diet presented decreased levels of renal xanthine oxidase and xanthine dehydrogenase and were only slightly proteinuric. Finally, rats shifted from a low-protein diet to a normal one developed massive proteinuria in spite of normal or slighly decreased levels of renal xanthine oxidase and xanthine dehydrogenase. We conlcude that a low-protein diet is effective in decreasing the levels of xanthine metabolising enzymes that are in part responsible for the renal damage due to Adriamycin. This is not however the unique mechanism by which the low-protein diet protects against the development of proteinuria in Adriamycin nephrosis; other factors must also be hypothesised.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalNephrology Dialysis Transplantation
Volume5
Issue numberSUPPL. 1
Publication statusPublished - 1990

Keywords

  • Adriamycin
  • Low-protein diet
  • Proteinuria
  • Xanthine oxidase

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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