TY - JOUR
T1 - Low protein Z levels in patients with peripheral arterial disease
AU - Sofi, Francesco
AU - Cesari, Francesca
AU - Pratesi, Giovanni
AU - Cellai, Anna Paola
AU - Pulli, Raffaele
AU - Pratesi, Carlo
AU - Gensini, Gian Franco
AU - Abbate, Rosanna
AU - Fedi, Sandra
PY - 2007/11
Y1 - 2007/11
N2 - Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (
AB - Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (
KW - Atherosclerosis
KW - Peripheral arterial disease
KW - Protein Z
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U2 - 10.1160/TH07-04-0300
DO - 10.1160/TH07-04-0300
M3 - Article
C2 - 18000618
AN - SCOPUS:36048998258
VL - 98
SP - 1114
EP - 1117
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 5
ER -