Low protein Z levels in patients with peripheral arterial disease

Francesco Sofi; Francesca Cesari; Giovanni Pratesi; Anna Paola Cellai; Raffaele Pulli; Carlo Pratesi; Gian Franco Gensini; Rosanna Abbate; Sandra Fedi

doi:10.1160/TH07-04-0300

Low protein Z levels in patients with peripheral arterial disease

Francesco Sofi, Francesca Cesari, Giovanni Pratesi, Anna Paola Cellai, Raffaele Pulli, Carlo Pratesi, Gian Franco Gensini, Rosanna Abbate, Sandra Fedi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (

Original language	English
Pages (from-to)	1114-1117
Number of pages	4
Journal	Thrombosis and Haemostasis
Volume	98
Issue number	5
DOIs	https://doi.org/10.1160/TH07-04-0300
Publication status	Published - Nov 2007

Keywords

Atherosclerosis
Peripheral arterial disease
Protein Z

ASJC Scopus subject areas

Hematology

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title = "Low protein Z levels in patients with peripheral arterial disease",

abstract = "Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (",

keywords = "Atherosclerosis, Peripheral arterial disease, Protein Z",

author = "Francesco Sofi and Francesca Cesari and Giovanni Pratesi and Cellai, {Anna Paola} and Raffaele Pulli and Carlo Pratesi and Gensini, {Gian Franco} and Rosanna Abbate and Sandra Fedi",

year = "2007",

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AU - Sofi, Francesco

AU - Cesari, Francesca

AU - Pratesi, Giovanni

AU - Cellai, Anna Paola

AU - Pulli, Raffaele

AU - Pratesi, Carlo

AU - Gensini, Gian Franco

AU - Abbate, Rosanna

AU - Fedi, Sandra

PY - 2007/11

Y1 - 2007/11

N2 - Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (

AB - Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (

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