Low protein Z levels in patients with peripheral arterial disease

Francesco Sofi, Francesca Cesari, Giovanni Pratesi, Anna Paola Cellai, Raffaele Pulli, Carlo Pratesi, Gian Franco Gensini, Rosanna Abbate, Sandra Fedi

Research output: Contribution to journalArticlepeer-review


Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p <0.05) lower in PAD patients [1,594 (89-3,635) ng/ml] compared to the healthy control group [1,728 (300-3,736) ng/ml]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (

Original languageEnglish
Pages (from-to)1114-1117
Number of pages4
JournalThrombosis and Haemostasis
Issue number5
Publication statusPublished - Nov 2007


  • Atherosclerosis
  • Peripheral arterial disease
  • Protein Z

ASJC Scopus subject areas

  • Hematology


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