Low rate of bleeding and thrombotic complications of oral anticoagulant therapy independent of age in the real-practice of an anticoagulation clinic

Daniela Poli, Emilia Antonucci, Alessandra Lombardi, Vieri Boddi, Gian Franco Gensini, Rosanna Abbate, Domenico Prisco

Research output: Contribution to journalArticlepeer-review

Abstract

Over past years, there has been a world-wide increase in oral anticoagulant treatment (OAT). This study was aimed at evaluating the efficacy and safety of OAT managing in a real-practice situation. Nine hundred and three consecutive unselected patients referred for the control of OAT to the Anticoagulation Clinic of the University of Florence were studied. The total follow-up period was 1679 patient-years. The rate of total, major and fatal bleeding events was 5.0, 1.1 and 0.06 per 100 patient-years, respectively. In patients with a target International Normalized Ratio (INR) ≥3, a significantly higher rate of bleeding (P=0.02) with respect to patients with a target INR

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalBlood Coagulation and Fibrinolysis
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Anticoagulation clinic
  • Bleeding complications
  • Oral anticoagulant therapy
  • Thrombotic complications

ASJC Scopus subject areas

  • Hematology

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