Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon

Ahidjo Ayouba, Gilbert Tene, Patrick Cunin, Yacouba Foupouapouognigni, Elisabeth Menu, Anfumbom Kfutwah, Jocelyn Thonnon, Gabriella Scarlatti, Marcel Monny-Lobé, Nicole Eteki, Charles Kouanfack, Michèle Tardy, Robert Leke, Maurice Nkam, Anne E. Nlend, Françoise Barré-Sinoussi, Paul M V Martin, Eric Nerrienet

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) of HIV in Yaoundé, Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVP-treated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system. Results: One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6% [13/123]; 95% confidence interval, 5.1-16) were infected and presented with high VLs, in general >500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87%) were considered not infected at 6-8 weeks of age. Conclusions: Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not >13% (16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.

Original languageEnglish
Pages (from-to)274-280
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume34
Issue number3
DOIs
Publication statusPublished - Nov 1 2003

Fingerprint

Nevirapine
Cameroon
HIV-1
Public Health
Mothers
HIV Infections
Labor Onset
Peripartum Period
Viral Load
Pregnant Women
HIV
Confidence Intervals

Keywords

  • BDNA
  • Cameroon
  • HIV-1
  • Mother-to-child
  • Nevirapine
  • Perinatal transmission
  • Prevention

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon. / Ayouba, Ahidjo; Tene, Gilbert; Cunin, Patrick; Foupouapouognigni, Yacouba; Menu, Elisabeth; Kfutwah, Anfumbom; Thonnon, Jocelyn; Scarlatti, Gabriella; Monny-Lobé, Marcel; Eteki, Nicole; Kouanfack, Charles; Tardy, Michèle; Leke, Robert; Nkam, Maurice; Nlend, Anne E.; Barré-Sinoussi, Françoise; Martin, Paul M V; Nerrienet, Eric.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 34, No. 3, 01.11.2003, p. 274-280.

Research output: Contribution to journalArticle

Ayouba, A, Tene, G, Cunin, P, Foupouapouognigni, Y, Menu, E, Kfutwah, A, Thonnon, J, Scarlatti, G, Monny-Lobé, M, Eteki, N, Kouanfack, C, Tardy, M, Leke, R, Nkam, M, Nlend, AE, Barré-Sinoussi, F, Martin, PMV & Nerrienet, E 2003, 'Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon', Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 3, pp. 274-280. https://doi.org/10.1097/00126334-200311010-00003
Ayouba, Ahidjo ; Tene, Gilbert ; Cunin, Patrick ; Foupouapouognigni, Yacouba ; Menu, Elisabeth ; Kfutwah, Anfumbom ; Thonnon, Jocelyn ; Scarlatti, Gabriella ; Monny-Lobé, Marcel ; Eteki, Nicole ; Kouanfack, Charles ; Tardy, Michèle ; Leke, Robert ; Nkam, Maurice ; Nlend, Anne E. ; Barré-Sinoussi, Françoise ; Martin, Paul M V ; Nerrienet, Eric. / Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon. In: Journal of Acquired Immune Deficiency Syndromes. 2003 ; Vol. 34, No. 3. pp. 274-280.
@article{ee3659fc9efe4afb93998803f5b22208,
title = "Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaound{\'e}, Cameroon",
abstract = "Objective: To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) of HIV in Yaound{\'e}, Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVP-treated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system. Results: One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6{\%} [13/123]; 95{\%} confidence interval, 5.1-16) were infected and presented with high VLs, in general >500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87{\%}) were considered not infected at 6-8 weeks of age. Conclusions: Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not >13{\%} (16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.",
keywords = "BDNA, Cameroon, HIV-1, Mother-to-child, Nevirapine, Perinatal transmission, Prevention",
author = "Ahidjo Ayouba and Gilbert Tene and Patrick Cunin and Yacouba Foupouapouognigni and Elisabeth Menu and Anfumbom Kfutwah and Jocelyn Thonnon and Gabriella Scarlatti and Marcel Monny-Lob{\'e} and Nicole Eteki and Charles Kouanfack and Mich{\`e}le Tardy and Robert Leke and Maurice Nkam and Nlend, {Anne E.} and Fran{\cc}oise Barr{\'e}-Sinoussi and Martin, {Paul M V} and Eric Nerrienet",
year = "2003",
month = "11",
day = "1",
doi = "10.1097/00126334-200311010-00003",
language = "English",
volume = "34",
pages = "274--280",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon

AU - Ayouba, Ahidjo

AU - Tene, Gilbert

AU - Cunin, Patrick

AU - Foupouapouognigni, Yacouba

AU - Menu, Elisabeth

AU - Kfutwah, Anfumbom

AU - Thonnon, Jocelyn

AU - Scarlatti, Gabriella

AU - Monny-Lobé, Marcel

AU - Eteki, Nicole

AU - Kouanfack, Charles

AU - Tardy, Michèle

AU - Leke, Robert

AU - Nkam, Maurice

AU - Nlend, Anne E.

AU - Barré-Sinoussi, Françoise

AU - Martin, Paul M V

AU - Nerrienet, Eric

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Objective: To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) of HIV in Yaoundé, Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVP-treated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system. Results: One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6% [13/123]; 95% confidence interval, 5.1-16) were infected and presented with high VLs, in general >500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87%) were considered not infected at 6-8 weeks of age. Conclusions: Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not >13% (16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.

AB - Objective: To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) of HIV in Yaoundé, Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVP-treated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system. Results: One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6% [13/123]; 95% confidence interval, 5.1-16) were infected and presented with high VLs, in general >500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87%) were considered not infected at 6-8 weeks of age. Conclusions: Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not >13% (16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.

KW - BDNA

KW - Cameroon

KW - HIV-1

KW - Mother-to-child

KW - Nevirapine

KW - Perinatal transmission

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=0242580983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242580983&partnerID=8YFLogxK

U2 - 10.1097/00126334-200311010-00003

DO - 10.1097/00126334-200311010-00003

M3 - Article

VL - 34

SP - 274

EP - 280

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 3

ER -