Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon

Ahidjo Ayouba, Gilbert Tene, Patrick Cunin, Yacouba Foupouapouognigni, Elisabeth Menu, Anfumbom Kfutwah, Jocelyn Thonnon, Gabriella Scarlatti, Marcel Monny-Lobé, Nicole Eteki, Charles Kouanfack, Michèle Tardy, Robert Leke, Maurice Nkam, Anne E. Nlend, Françoise Barré-Sinoussi, Paul M V Martin, Eric Nerrienet

Research output: Contribution to journalArticle

Abstract

Objective: To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) of HIV in Yaoundé, Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVP-treated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system. Results: One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6% [13/123]; 95% confidence interval, 5.1-16) were infected and presented with high VLs, in general >500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87%) were considered not infected at 6-8 weeks of age. Conclusions: Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not >13% (16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.

Original languageEnglish
Pages (from-to)274-280
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume34
Issue number3
DOIs
Publication statusPublished - Nov 1 2003

Keywords

  • BDNA
  • Cameroon
  • HIV-1
  • Mother-to-child
  • Nevirapine
  • Perinatal transmission
  • Prevention

ASJC Scopus subject areas

  • Virology
  • Immunology

Fingerprint Dive into the research topics of 'Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon'. Together they form a unique fingerprint.

  • Cite this

    Ayouba, A., Tene, G., Cunin, P., Foupouapouognigni, Y., Menu, E., Kfutwah, A., Thonnon, J., Scarlatti, G., Monny-Lobé, M., Eteki, N., Kouanfack, C., Tardy, M., Leke, R., Nkam, M., Nlend, A. E., Barré-Sinoussi, F., Martin, P. M. V., & Nerrienet, E. (2003). Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaoundé, Cameroon. Journal of Acquired Immune Deficiency Syndromes, 34(3), 274-280. https://doi.org/10.1097/00126334-200311010-00003