Low-risk diet for colorectal cancer in Italy

S. Calza, M. Ferraroni, C. LaVecchia, S. Franceschi, A. Decarli

Research output: Contribution to journalArticlepeer-review


An innovative approach was used to define a low-risk diet for colorectal cancer from a multicentric case-control study of 1953 incident cases and 4154 hospital controls from Italy. A logistic regression model was fitted on the reported intake of five macronutrients, and the estimated coefficients were used to compute a diet-related logistic risk score (LRS). The mean of LRS within risk decile ranged from 0.89 to 1.86. Total energy intake and absolute consumption of each macronutrient increased with increasing LRS. In relative terms, however, starch intake showed an almost threefold increase across subsequent score levels, while a decline was observed for unsaturated fat, sugar and protein. Saturated fat consumption remained fairly stable in relative terms. When food groups were considered, bread and cereals dishes, cakes and desserts and refined sugar were positively associated, while the consumption of vegetables, fruit, fish, poultry and olive oils was inversely associated with LRS.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalEuropean Journal of Cancer Prevention
Issue number6
Publication statusPublished - 2001


  • Colorectal neoplasms
  • Diet
  • Macronutrient
  • Risk score

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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