Low risk of thrombosis in family members of patients with hyperhomocysteinaemia

Ida Martinelli, Paolo Bucciarelli, Maddalena L. Zighetti, Anna Cafro, Pier M. Mannucci

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mild to moderate hyperhomocysteinaemia, a metabolic disorder due to genetic and/or acquired factors, is associated with an increased risk of venous and arterial thrombosis. To establish whether measuring homocysteine in members of families of hyperhomocysteinaemic patients is warranted, we investigated 169 relatives of patients diagnosed with hyperhomocysteinaemia after they developed arterial or venous thrombosis. The prevalence of hyperhomocysteinaemia was 16.6%; the relative risk of thrombosis in relatives with hyperhomocysteinaemia compared to those without was 1.2 (odds ratio; 95% CI 0.24-4.2), with similarly low absolute annual incidences of thrombosis (0.28% and 0.24%). The low prevalence of hyperhomocysteinaemia among relatives of patients with this metabolic disorder, and their low risk of thrombosis, do not justify family screening.

Original languageEnglish
Pages (from-to)709-711
Number of pages3
JournalBritish Journal of Haematology
Volume117
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Hyperhomocysteinemia
Thrombosis
Venous Thrombosis
Homocysteine
Odds Ratio
Incidence

Keywords

  • Coagulation
  • Homocysteine
  • Risk factor

ASJC Scopus subject areas

  • Hematology

Cite this

Low risk of thrombosis in family members of patients with hyperhomocysteinaemia. / Martinelli, Ida; Bucciarelli, Paolo; Zighetti, Maddalena L.; Cafro, Anna; Mannucci, Pier M.

In: British Journal of Haematology, Vol. 117, No. 3, 2002, p. 709-711.

Research output: Contribution to journalArticle

@article{1dcd4b096a0441d9a41a60eabe862b0c,
title = "Low risk of thrombosis in family members of patients with hyperhomocysteinaemia",
abstract = "Mild to moderate hyperhomocysteinaemia, a metabolic disorder due to genetic and/or acquired factors, is associated with an increased risk of venous and arterial thrombosis. To establish whether measuring homocysteine in members of families of hyperhomocysteinaemic patients is warranted, we investigated 169 relatives of patients diagnosed with hyperhomocysteinaemia after they developed arterial or venous thrombosis. The prevalence of hyperhomocysteinaemia was 16.6{\%}; the relative risk of thrombosis in relatives with hyperhomocysteinaemia compared to those without was 1.2 (odds ratio; 95{\%} CI 0.24-4.2), with similarly low absolute annual incidences of thrombosis (0.28{\%} and 0.24{\%}). The low prevalence of hyperhomocysteinaemia among relatives of patients with this metabolic disorder, and their low risk of thrombosis, do not justify family screening.",
keywords = "Coagulation, Homocysteine, Risk factor",
author = "Ida Martinelli and Paolo Bucciarelli and Zighetti, {Maddalena L.} and Anna Cafro and Mannucci, {Pier M.}",
year = "2002",
doi = "10.1046/j.1365-2141.2002.03489.x",
language = "English",
volume = "117",
pages = "709--711",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "3",

}

TY - JOUR

T1 - Low risk of thrombosis in family members of patients with hyperhomocysteinaemia

AU - Martinelli, Ida

AU - Bucciarelli, Paolo

AU - Zighetti, Maddalena L.

AU - Cafro, Anna

AU - Mannucci, Pier M.

PY - 2002

Y1 - 2002

N2 - Mild to moderate hyperhomocysteinaemia, a metabolic disorder due to genetic and/or acquired factors, is associated with an increased risk of venous and arterial thrombosis. To establish whether measuring homocysteine in members of families of hyperhomocysteinaemic patients is warranted, we investigated 169 relatives of patients diagnosed with hyperhomocysteinaemia after they developed arterial or venous thrombosis. The prevalence of hyperhomocysteinaemia was 16.6%; the relative risk of thrombosis in relatives with hyperhomocysteinaemia compared to those without was 1.2 (odds ratio; 95% CI 0.24-4.2), with similarly low absolute annual incidences of thrombosis (0.28% and 0.24%). The low prevalence of hyperhomocysteinaemia among relatives of patients with this metabolic disorder, and their low risk of thrombosis, do not justify family screening.

AB - Mild to moderate hyperhomocysteinaemia, a metabolic disorder due to genetic and/or acquired factors, is associated with an increased risk of venous and arterial thrombosis. To establish whether measuring homocysteine in members of families of hyperhomocysteinaemic patients is warranted, we investigated 169 relatives of patients diagnosed with hyperhomocysteinaemia after they developed arterial or venous thrombosis. The prevalence of hyperhomocysteinaemia was 16.6%; the relative risk of thrombosis in relatives with hyperhomocysteinaemia compared to those without was 1.2 (odds ratio; 95% CI 0.24-4.2), with similarly low absolute annual incidences of thrombosis (0.28% and 0.24%). The low prevalence of hyperhomocysteinaemia among relatives of patients with this metabolic disorder, and their low risk of thrombosis, do not justify family screening.

KW - Coagulation

KW - Homocysteine

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=0036105443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036105443&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2002.03489.x

DO - 10.1046/j.1365-2141.2002.03489.x

M3 - Article

VL - 117

SP - 709

EP - 711

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 3

ER -