Low risk of transmission of the human immunodefiency virus by a solvent-detergent-treated commercial factor VIII concentrate

T. Di Paolantonio, G. Mariani, A. Chirardini, A. Gringeri, P. Mannuccio Mannucci, L. Mastrullo, R. De Biasi, G. Giustarini, M. Morfini, M. Schiavoni, N. Ciavarella, G. Zehender, A. R. Zanetti

Research output: Contribution to journalArticlepeer-review

Abstract

A study evaluating the risk of a commercial factor VIII (FVIII) concentrate's transmitting the human immunodeficiency virus (HIV) was carried out on hemophiliacs, by using multiple serological markers and the polymerase chain reaction (PCR). Twenty-nine hemophiliacs, negative for HIV antibodies, were treated for 18 months with a concentrate that had been inactivated by solvent-detergent. HIV-1 antibodies and antigen were assayed during the follow-up period. At the end of the study, all patients were also tested by the HIV 1+2 combined antibody assay; Western blot (WB) antibody analysis; and in eight cases, by an HIV-1 PCR technique. Patients received a yearly median FVIII dose of 35,330 IU (range 3,300-306,000); the median number of lots given to each patient was 6 (1-45). During the follow-up period and at the end of the study, HIV-1 antibodies and antigen were not detected in any of the subjects. The HIV 1+2 combined assay and WB analysis carried out only at the end of the study were negative. HIV-1 PCR was negative in all the tested patients. This study was shown that this solvent-detergent-treated FVIII concentrate did not transmit HIV.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalJournal of Medical Virology
Volume36
Issue number2
Publication statusPublished - 1992

Keywords

  • Chemical inactivation
  • HIV safety
  • HIV-1 PCR
  • Viral inactivation

ASJC Scopus subject areas

  • Virology

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