Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia

N. Napoli; Enrico Carmina; Salvatore Bucchieri; C. Sferrazza; G. B. Rini; G. Di Fede

doi:10.1016/j.bone.2005.11.018

Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia

N. Napoli, Enrico Carmina, Salvatore Bucchieri, C. Sferrazza, G. B. Rini, G. Di Fede

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Adult thalassemic patients have reduced bone mass due to disturbances in several different mechanisms affecting bone turnover. To determine if vitamin D deficiency contributes to the low bone mass of adult thalassemic subjects, we studied serum 25-OH-vitamin D levels in 90 patients (age ranging between 21 and 48 years) affected with thalassemia major (TM) and 35 (age 21-56 years) with thalassemia intermedia (TI). TM patients had been receiving regular transfusions from the age of 2 years and had increased serum ferritin, glutamic oxalacetic transaminase, glutamic piruvic transaminase as well as low bone density (L1-L4 Z score -2.07 ± 0.2). TI patients did not receive transfusions, but their ferritin levels were increased as well (520.3 ± 138,1). 8 TM patients (10.1%) and 4 TI (11.4%) had serum 25-OH-vitamin D less than 10.4 ng/ml and were considered presenting an absolute deficiency of vitamin D. Mean 25-OH-vitamin D was significantly (P

Original language	English
Pages (from-to)	888-892
Number of pages	5
Journal	Bone
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.bone.2005.11.018
Publication status	Published - Jun 2006

Keywords

Iron overload
Osteopenia
Osteoporosis
Thalassemia major
Vitamin D

ASJC Scopus subject areas

Physiology
Hematology

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abstract = "Adult thalassemic patients have reduced bone mass due to disturbances in several different mechanisms affecting bone turnover. To determine if vitamin D deficiency contributes to the low bone mass of adult thalassemic subjects, we studied serum 25-OH-vitamin D levels in 90 patients (age ranging between 21 and 48 years) affected with thalassemia major (TM) and 35 (age 21-56 years) with thalassemia intermedia (TI). TM patients had been receiving regular transfusions from the age of 2 years and had increased serum ferritin, glutamic oxalacetic transaminase, glutamic piruvic transaminase as well as low bone density (L1-L4 Z score -2.07 ± 0.2). TI patients did not receive transfusions, but their ferritin levels were increased as well (520.3 ± 138,1). 8 TM patients (10.1%) and 4 TI (11.4%) had serum 25-OH-vitamin D less than 10.4 ng/ml and were considered presenting an absolute deficiency of vitamin D. Mean 25-OH-vitamin D was significantly (P ",

keywords = "Iron overload, Osteopenia, Osteoporosis, Thalassemia major, Vitamin D",

author = "N. Napoli and Enrico Carmina and Salvatore Bucchieri and C. Sferrazza and Rini, {G. B.} and {Di Fede}, G.",

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AU - Carmina, Enrico

AU - Bucchieri, Salvatore

AU - Sferrazza, C.

AU - Rini, G. B.

AU - Di Fede, G.

PY - 2006/6

Y1 - 2006/6

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KW - Thalassemia major

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Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia

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Keywords

ASJC Scopus subject areas

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