Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia

N. Napoli, Enrico Carmina, Salvatore Bucchieri, C. Sferrazza, G. B. Rini, G. Di Fede

Research output: Contribution to journalArticlepeer-review

Abstract

Adult thalassemic patients have reduced bone mass due to disturbances in several different mechanisms affecting bone turnover. To determine if vitamin D deficiency contributes to the low bone mass of adult thalassemic subjects, we studied serum 25-OH-vitamin D levels in 90 patients (age ranging between 21 and 48 years) affected with thalassemia major (TM) and 35 (age 21-56 years) with thalassemia intermedia (TI). TM patients had been receiving regular transfusions from the age of 2 years and had increased serum ferritin, glutamic oxalacetic transaminase, glutamic piruvic transaminase as well as low bone density (L1-L4 Z score -2.07 ± 0.2). TI patients did not receive transfusions, but their ferritin levels were increased as well (520.3 ± 138,1). 8 TM patients (10.1%) and 4 TI (11.4%) had serum 25-OH-vitamin D less than 10.4 ng/ml and were considered presenting an absolute deficiency of vitamin D. Mean 25-OH-vitamin D was significantly (P 

Original languageEnglish
Pages (from-to)888-892
Number of pages5
JournalBone
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Iron overload
  • Osteopenia
  • Osteoporosis
  • Thalassemia major
  • Vitamin D

ASJC Scopus subject areas

  • Physiology
  • Hematology

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