TY - JOUR
T1 - Low serum trough levels are associated with post-surgical recurrence in Crohn's disease patients undergoing prophylaxis with adalimumab
AU - Bodini, Giorgia
AU - Savarino, Vincenzo
AU - Peyrin-Biroulet, Laurent
AU - de Cassan, Chiara
AU - Dulbecco, Pietro
AU - Baldissarro, Isabella
AU - Fazio, Valentina
AU - Giambruno, Elisa
AU - Savarino, Edoardo
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: Whether therapeutic drug monitoring of biologic therapy can predict the efficacy of adalimumab to prevent postoperative Crohn's disease recurrence is unknown. Aim: To investigate whether adalimumab trough levels and anti-adalimumab antibodies correlate with endoscopic and clinical outcomes in a series of patients treated with prophylactic adalimumab monotherapy after resective surgery. Methods: Post hoc analysis of a randomized, mesalamine-controlled trial. Adalimumab trough levels and antibodies were analysed every 8 weeks for 2 years using an homogeneous mobility shift assay. Results: At two years, 1/6 patient had clinical recurrence and 1/6 patient had endoscopic and clinical recurrence. At baseline (9.5 vs. 14.4. mcg/mL) and during follow-up [7.5 (4.4-9.8) vs. 13.9 (8.9-23.6). mcg/mL, p
AB - Background: Whether therapeutic drug monitoring of biologic therapy can predict the efficacy of adalimumab to prevent postoperative Crohn's disease recurrence is unknown. Aim: To investigate whether adalimumab trough levels and anti-adalimumab antibodies correlate with endoscopic and clinical outcomes in a series of patients treated with prophylactic adalimumab monotherapy after resective surgery. Methods: Post hoc analysis of a randomized, mesalamine-controlled trial. Adalimumab trough levels and antibodies were analysed every 8 weeks for 2 years using an homogeneous mobility shift assay. Results: At two years, 1/6 patient had clinical recurrence and 1/6 patient had endoscopic and clinical recurrence. At baseline (9.5 vs. 14.4. mcg/mL) and during follow-up [7.5 (4.4-9.8) vs. 13.9 (8.9-23.6). mcg/mL, p
KW - Adalimumab
KW - Anti-tumour necrosis factor alpha antibodies
KW - Crohn's disease
KW - Post-surgical recurrence
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U2 - 10.1016/j.dld.2014.07.171
DO - 10.1016/j.dld.2014.07.171
M3 - Article
C2 - 25169962
AN - SCOPUS:84908215471
VL - 46
SP - 1043
EP - 1046
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 11
ER -