Abstract
Objectives: To evaluate somatostatin receptor 2A (SSTR2A) and dopamine receptor 2 (DR2) protein expression in somatotropinomas and to relate it to response to somatostatin analogues (SA). Design and patients: SSTR2A and DR2 expression was analyzed by immunohistochemistry in 88 somatotropinomas from patients submitted to either pre-surgical or adjuvant SA treatment. Tumors were scored according to percentage of immunostained cells: 0 (50%). Relation between protein expression and response to SA was performed in 66 patients. Response to SA was assessed by percent IGF-I reduction, being considered as an IGF-I per cent reduction higher than 50%. Disease control was also assessed (GH
Original language | English |
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Pages (from-to) | 38-43 |
Number of pages | 6 |
Journal | Journal of Endocrinological Investigation |
Volume | 36 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2013 |
Keywords
- Acromegaly
- Dopamine receptors
- Immunohistochemistry
- Somatostatin analogues
- Somatostatin receptors
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology