Low testosterone levels are associated with coronary artery disease in male patients with angina

G. M C Rosano, I. Sheiban, R. Massaro, P. Pagnotta, G. Marazzi, C. Vitale, G. Mercuro, M. Volterrani, A. Aversa, M. Fini

Research output: Contribution to journalArticlepeer-review


Historically, high androgen levels have been linked with an increased risk for coronary artery disease (CAD). However, more recent data suggest that low androgen levels are associated with adverse cardiovascular risk factors, including an atherogenic lipid profile, obesity and insulin resistance. The aim of the present study was to evaluate the relationship between plasma sex hormone levels and presence and degree of CAD in patients undergoing coronary angiography and in matched controls. We evaluated 129 consecutive male patients (mean age 58±4 years, range 43-72 years) referred for diagnostic coronary angiography because of symptoms suggestive of CAD, but without acute coronary syndromes or prior diagnosis of hypogonadism. Patients were matched with healthy volunteers. Out of 129 patients, 119 had proven CAD; in particular, 32 of them had one, 63 had two and 24 had three vessel disease, respectively. Patients had significantly lower levels of testosterone than controls (9.8±6.5 and 13.5±5.4 nmol/l, P

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalInternational Journal of Impotence Research
Issue number2
Publication statusPublished - Mar 25 2007


  • Angina
  • Coronary artery disease
  • Oestrogen
  • Sex hormones
  • Testosterone

ASJC Scopus subject areas

  • Urology


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