Low versus high cell turnover in diffusely growing non-Hodgkin's lymphomas

D. Spina, L. Leoncini, M. T. Del Vecchio, T. Megha, C. Minacci, S. A. Poggi, S. Pileri, P. Tosi, R. Kraft, J. A. Laissue, H. Cottier

Research output: Contribution to journalArticlepeer-review


Cell loss, perhaps as important as cell production in determining the size of an expanding cell population, has not usually been registered in quantitative cellular kinetic analyses of neoplastic disorders. The present retrospective study on various types and subtypes of non-Hodgkin's lymphomas (NHLs; n=170) was designed to test the usefulness of a novel additional parameter, the 'turnover index' (TI), which is the sum per case of the mitotic index and the apoptotic index. Results document that TIs clearly distinguished between categories and subtypes of NHLs according to the Kiel classification. Cluster analysis of TIs plotted against the percentage of Ki-67-positive cells per case revealed that about one-third of the high-grade malignancy lymphomas actually belonged to the low-turnover lymphomas. Overall survival was longer in the low- than in the high-turnover group of lymphomas. Assessment of TIs can, for practical diagnostic purposes, be replaced by counting mitotic figures and apoptotic cells in several high-power fields. The TI concept may help to interpret the kinetics of NHLs in terms of accumulation vs. proliferation of cells.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalJournal of Pathology
Issue number4
Publication statusPublished - 1995


  • Apoptosis
  • Cell turnover
  • Malignant lymphomas
  • Mitosis
  • Neoplastic growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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