Low vitamin B6 levels and the risk of recurrent venous thromboembolism

Gregor Hron, Rossana Lombardi, Sabine Eichinger, Anna Lecchi, Paul A. Kyrie, Marco Cattaneo

Research output: Contribution to journalArticle

Abstract

Low plasma vitamin B6, measured as pyridoxal-5′-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence was 22.5% (95% CI 13.6-31.5%) among patients with PLP ≤23.3 nmol/L and 14.4% (11.5-17.4%) among those with PLP >23.3 nmol/L (p=0.01). Patients with PLP ≤23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.

Original languageEnglish
Pages (from-to)1250-1253
Number of pages4
JournalHaematologica
Volume92
Issue number9
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Vitamin B 6
Pyridoxal Phosphate
Venous Thromboembolism
Recurrence
Homocysteine

Keywords

  • Deep vein thrombosis
  • Homocysteine
  • Pulmonary embolism
  • Risk factors
  • Vitamin B6

ASJC Scopus subject areas

  • Hematology

Cite this

Hron, G., Lombardi, R., Eichinger, S., Lecchi, A., Kyrie, P. A., & Cattaneo, M. (2007). Low vitamin B6 levels and the risk of recurrent venous thromboembolism. Haematologica, 92(9), 1250-1253. https://doi.org/10.3324/haematol.11318

Low vitamin B6 levels and the risk of recurrent venous thromboembolism. / Hron, Gregor; Lombardi, Rossana; Eichinger, Sabine; Lecchi, Anna; Kyrie, Paul A.; Cattaneo, Marco.

In: Haematologica, Vol. 92, No. 9, 09.2007, p. 1250-1253.

Research output: Contribution to journalArticle

Hron, G, Lombardi, R, Eichinger, S, Lecchi, A, Kyrie, PA & Cattaneo, M 2007, 'Low vitamin B6 levels and the risk of recurrent venous thromboembolism', Haematologica, vol. 92, no. 9, pp. 1250-1253. https://doi.org/10.3324/haematol.11318
Hron, Gregor ; Lombardi, Rossana ; Eichinger, Sabine ; Lecchi, Anna ; Kyrie, Paul A. ; Cattaneo, Marco. / Low vitamin B6 levels and the risk of recurrent venous thromboembolism. In: Haematologica. 2007 ; Vol. 92, No. 9. pp. 1250-1253.
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