Low vitamin D levels are associated with the presence of serum cryoglobulins in patients with chronic HCV infection

Ivan Gentile, Filomena Scarano, Anna Celotti, Enrica De Iuliis, Rosanna Scarano, Vincenza Granata, Biagio Pinchera, Mariangela Meola, Antonietta D'Ambra, Mauro Piccirillo, Flaviano Di Paola, Ernesta Cavalcanti, Francesco Izzo, Nicola Scarpato, Guglielmo Borgia

Research output: Contribution to journalArticle

Abstract

Background/Aim: Mixed Cryoglobulinemia (MC) represents the most frequent extrahepatic manifestation of chronic Hepatitis C Virus (HCV) infection. Its pathogenic mechanisms involve HCV-induced chronic stimulation of B-lymphocytes. We aimed to investigate the relationship between serum levels of vitamin D (a regulator of immune response) and the presence of serum cryoglobulins in the setting of HCV infection. Patients and Methods: We evaluated the serum concentration of 25(OH)vitamin D and cryoglobulins in 106 patients with chronic HCV infection. Results: Thirty patients (28.3%) showed the presence of serum cryoglobulins. For the cohort overall, the median serum 25(OH)vitamin D level was 10.95 ng/ml. Patients with serum cryoglobulins had significantly lower levels of 25(OH)vitamin D (5.61 ng/ml) than those without (13.65 ng/ml, p=0.029). At multivariate analysis, severe hypovitaminosis [i.e. 25(OH)vitamin D

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalIn Vivo
Volume29
Issue number3
Publication statusPublished - May 1 2015

Keywords

  • Extrahepatic manifestation
  • Hepatitis C
  • Immune regulation
  • Low-antigen diet
  • Lymphoma
  • Metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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    Gentile, I., Scarano, F., Celotti, A., De Iuliis, E., Scarano, R., Granata, V., Pinchera, B., Meola, M., D'Ambra, A., Piccirillo, M., Di Paola, F., Cavalcanti, E., Izzo, F., Scarpato, N., & Borgia, G. (2015). Low vitamin D levels are associated with the presence of serum cryoglobulins in patients with chronic HCV infection. In Vivo, 29(3), 399-404.