Low-volume disease in endometrial cancer: The role of micrometastasis and isolated tumor cells

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5 Citations (Scopus)

Abstract

Nodal assessment represents an integral part of staging procedure for endometrial cancer. The widespread diffusion of sentinel node mapping determinates a phenomenon of migration from stage I to stage III disease, especially for low-risk endometrial cancer patients. The adoption of sentinel node mapping and pathological ultrastaging increase the detection of low volume disease (i.e., micrometastasis and isolated tumor cells), being low volume disease detected in >30% of patients with positive nodes. The prognostic role of low volume disease is discussed as well as the possible adjuvant strategies for patients diagnosed with micrometastasis and isolated tumor cells. The role of further prospective treatments in endometrial cancer, including molecular and genetic profiling, is critically reviewed.

Original languageEnglish
Pages (from-to)670-675
Number of pages6
JournalGynecologic Oncology
Volume153
Issue number3
DOIs
Publication statusPublished - Jun 2019

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Neoplasm Micrometastasis
Endometrial Neoplasms
Neoplasms
Molecular Biology
cyhalothrin
Therapeutics

Keywords

  • Endometrial cancer
  • Micrometastasis, isolated tumor cells
  • Sentinel node mapping
  • Ultrastaging

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

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title = "Low-volume disease in endometrial cancer: The role of micrometastasis and isolated tumor cells",
abstract = "Nodal assessment represents an integral part of staging procedure for endometrial cancer. The widespread diffusion of sentinel node mapping determinates a phenomenon of migration from stage I to stage III disease, especially for low-risk endometrial cancer patients. The adoption of sentinel node mapping and pathological ultrastaging increase the detection of low volume disease (i.e., micrometastasis and isolated tumor cells), being low volume disease detected in >30{\%} of patients with positive nodes. The prognostic role of low volume disease is discussed as well as the possible adjuvant strategies for patients diagnosed with micrometastasis and isolated tumor cells. The role of further prospective treatments in endometrial cancer, including molecular and genetic profiling, is critically reviewed.",
keywords = "Endometrial cancer, Micrometastasis, isolated tumor cells, Sentinel node mapping, Ultrastaging",
author = "Giorgio Bogani and Andrea Mariani and Biagio Paolini and Antonino Ditto and Francesco Raspagliesi",
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T1 - Low-volume disease in endometrial cancer

T2 - The role of micrometastasis and isolated tumor cells

AU - Bogani, Giorgio

AU - Mariani, Andrea

AU - Paolini, Biagio

AU - Ditto, Antonino

AU - Raspagliesi, Francesco

PY - 2019/6

Y1 - 2019/6

N2 - Nodal assessment represents an integral part of staging procedure for endometrial cancer. The widespread diffusion of sentinel node mapping determinates a phenomenon of migration from stage I to stage III disease, especially for low-risk endometrial cancer patients. The adoption of sentinel node mapping and pathological ultrastaging increase the detection of low volume disease (i.e., micrometastasis and isolated tumor cells), being low volume disease detected in >30% of patients with positive nodes. The prognostic role of low volume disease is discussed as well as the possible adjuvant strategies for patients diagnosed with micrometastasis and isolated tumor cells. The role of further prospective treatments in endometrial cancer, including molecular and genetic profiling, is critically reviewed.

AB - Nodal assessment represents an integral part of staging procedure for endometrial cancer. The widespread diffusion of sentinel node mapping determinates a phenomenon of migration from stage I to stage III disease, especially for low-risk endometrial cancer patients. The adoption of sentinel node mapping and pathological ultrastaging increase the detection of low volume disease (i.e., micrometastasis and isolated tumor cells), being low volume disease detected in >30% of patients with positive nodes. The prognostic role of low volume disease is discussed as well as the possible adjuvant strategies for patients diagnosed with micrometastasis and isolated tumor cells. The role of further prospective treatments in endometrial cancer, including molecular and genetic profiling, is critically reviewed.

KW - Endometrial cancer

KW - Micrometastasis, isolated tumor cells

KW - Sentinel node mapping

KW - Ultrastaging

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