Low vs Standard Pneumoperitoneum Pressure During Laparoscopic Hysterectomy: Prospective Randomized Trial

Giorgio Bogani, Stefano Uccella, Antonella Cromi, Maurizio Serati, Jvan Casarin, Ciro Pinelli, Fabio Ghezzi

Research output: Contribution to journalArticlepeer-review


Study Objective: To compare the use of low pneumoperitoneum pressure (LPP; 8 mm Hg) vs standard pneumoperitoneum pressure (SPP; 12 mm Hg) during mini-laparoscopic hysterectomy (MLH). Design: Randomized controlled trial (Canadian Task Force classification I). Setting: Tertiary care center. Patients: Forty-two consecutive women scheduled to undergo MLH to treat benign uterine disease. Interventions: Women were randomly selected to undergo MLH using LPP (n = 20) or SPP (n = 22). MLH was performed via 3-mm ancillary ports. Measurements and Main Results: The primary outcome was to evaluate changes in abdominal and shoulder-tip pain via a 100-mm visual analog scale at 1, 3, and 24 hours postoperatively. All procedures were completed via mini-laparoscopy without the need to increase intra-abdominal pressure or convert to conventional laparoscopy or open surgery. Intraoperatively, 1 episode of severe bradycardia occurred in the LPP group, whereas no intraoperative complications were recorded in the SPP group (p = .47). No postoperative complications were recorded (p > .99). Abdominal pain was similar between groups at each time point. Incidence and intensity of shoulder-tip pain at 1 and 3 hours postoperatively was lower in the LPP group than in the SPP group (p <.05), whereas no between-group differences were observed at 24 hours (p > .05). Rescue analgesic requirement did not differ statistically between the LPP and SPP groups (20% vs 41%, respectively; p = .19; odds ratio, 2.7; 95% confidence interval, 0.69-11.08). Conclusion: In experienced hands, use of LPP is safe and feasible. During performance of MLH, compared with SPP, LPP is a simple method that offers advantages of less shoulder-tip pain.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalJournal of Minimally Invasive Gynecology
Issue number3
Publication statusPublished - 2014


  • Hysterectomy
  • Laparoscopy
  • Mini-laparoscopy
  • Pain
  • Pneumoperitoneum pressure

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)


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